E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.
E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.
复制标题
DOI：
10.1038/s41467-022-33203-1
复制
发表时间：
2022-10-25
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
电子烟的使用量激增，但其对健康的长期影响尚不清楚。含有尼古丁和丙烯醛（燃烧和电子烟的副产品）的电子烟气雾剂可能通过自主神经失衡损害心脏电生理。在这里，我们在小鼠的心电图中显示，急性吸入电子烟气溶胶会干扰心脏传导，部分是通过副交感神经调节。我们证明，与丙烯醛或可燃香烟烟雾类似，来自电子烟溶剂的气溶胶（植物甘油和丙二醇）在吸入暴露期间诱导心动过缓、慢速心律失常和心率变异性升高，并具有相反的暴露后效应。这些影响在含有尼古丁的烟草或薄荷味气雾剂中比较轻微，在雌性小鼠中也是如此。然而，薄荷味和PG气雾剂也会增加室性心律失常和增强早期心室复极（J振幅），而薄荷醇独特地改变心房和房室传导。接触由植物甘油及其副产品丙烯醛制成的电子烟气雾剂会降低心率和早期复极。溶剂气溶胶对心室复极和心率变异性的促心律失常作用部分取决于副交感神经调节，而室性心律失常与依赖于尼古丁存在的早期复极呈正相关。我们的研究表明，电子烟的化学成分可能会引发促心律失常的变化和刺激自主神经反射，从而增加心脏风险。尽管电子烟的长期影响未知，但其使用量仍在增加。在这里，作者表明，电子烟气溶胶改变了小鼠的心脏传导、复极化和自主调节，这取决于电子烟液体的化学成分，部分是通过副交感神经调节。
E-cigarette use has surged, but the long-term health effects remain unknown. E-cigarette aerosols containing nicotine and acrolein, a combustion and e-cigarette byproduct, may impair cardiac electrophysiology through autonomic imbalance. Here we show in mouse electrocardiograms that acute inhalation of e-cigarette aerosols disturbs cardiac conduction, in part through parasympathetic modulation. We demonstrate that, similar to acrolein or combustible cigarette smoke, aerosols from e-cigarette solvents (vegetable glycerin and propylene glycol) induce bradycardia, bradyarrhythmias, and elevations in heart rate variability during inhalation exposure, with inverse post-exposure effects. These effects are slighter with tobacco- or menthol-flavored aerosols containing nicotine, and in female mice. Yet, menthol-flavored and PG aerosols also increase ventricular arrhythmias and augment early ventricular repolarization (J amplitude), while menthol uniquely alters atrial and atrioventricular conduction. Exposure to e-cigarette aerosols from vegetable glycerin and its byproduct, acrolein, diminish heart rate and early repolarization. The pro-arrhythmic effects of solvent aerosols on ventricular repolarization and heart rate variability depend partly on parasympathetic modulation, whereas ventricular arrhythmias positively associate with early repolarization dependent on the presence of nicotine. Our study indicates that chemical constituents of e-cigarettes could contribute to cardiac risk by provoking pro-arrhythmic changes and stimulating autonomic reflexes. The use of E-cigarettes has increased despite the unknown long-term effects. Here the authors show that e-cigarette aerosols alter cardiac conduction, repolarization, and autonomic regulation in mice, contingent on the chemical composition of e-liquids and partly through parasympathetic modulation.
登录
查看更多内容
DOI：
10.1016/j.jadohealth.2017.11.301
发表时间：
2018-05
期刊：
The Journal of adolescent health : official publication of the Society for Adolescent Medicine
影响因子：
--
作者：
East K;Hitchman SC;Bakolis I;Williams S;Cheeseman H;Arnott D;McNeill A
通讯作者：
McNeill A
影响因子：
33.9
作者：
Blount, Benjamin C.;Karwowski, Mateusz P.;Pirkle, James L.
通讯作者：
Pirkle, James L.
影响因子：
5.2
作者：
Evans, Sarah E.;Hoffman, Allison C.
通讯作者：
Hoffman, Allison C.
影响因子：
3.8
作者：
Carll, Alex P.;Hazari, Mehdi S.;Farraj, Aimen K.
通讯作者：
Farraj, Aimen K.
影响因子：
19.7
作者：
Caporale, Alessandra;Langham, Michael C.;Wehrli, Felix W.
通讯作者：
Wehrli, Felix W.