Bias in estimation of hippocampal atrophy using deformation-based morphometry arises from asymmetric global normalization: an illustration in ADNI 3 T MRI data.
Bias in estimation of hippocampal atrophy using deformation-based morphometry arises from asymmetric global normalization: an illustration in ADNI 3 T MRI data.
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DOI：
10.1016/j.neuroimage.2009.12.007
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发表时间：
2010-04-01
期刊：
影响因子：
5.7
通讯作者：
Craige, Caryne
中科院分区：
文献类型：
--
作者：
Yushkevich, Paul A.;Avants, Brian B.;Das, Sandhitsu R.;Pluta, John;Altinay, Murat;Craige, Caryne
关键词：
神经退行性疾病和治疗引起的脑变化的测量是神经成像的基本任务之一。基于形变的形态计量学(DBM)一直被认为是一种有效和灵敏的工具来估计大脑区域体积随时间的变化。本文论证了直接应用DBM来估计海马体体积的变化会导致很大的偏差，即高估了海马体体积的变化率。在ADNI数据中，这种偏差表现为与6个月和12个月海马区萎缩率相适应的回归线的非零截距。通过应用DBM对同一天获得的受试者进行重复扫描，进一步证实了这种偏见。这种偏差似乎是纵向图像配准过程中基线和后续图像内插不对称的结果。纠正这种不对称性导致了无偏差的萎缩估计。
Measurement of brain change due to neurodegenerative disease and treatment is one of the fundamental tasks of neuroimaging. Deformation-based morphometry (DBM) has been long recognized as an effective and sensitive tool for estimating the change in the volume of brain regions over time. This paper demonstrates that a straightforward application of DBM to estimate the change in the volume of the hippocampus can result in substantial bias, i.e., an overestimation of the rate of change in hippocampal volume. In ADNI data, this bias is manifested as a non-zero intercept of the regression line fitted to the 6 and 12 month rates of hippocampal atrophy. The bias is further confirmed by applying DBM to repeat scans of subjects acquired on the same day. This bias appears to be the result of asymmetry in the interpolation of baseline and followup images during longitudinal image registration. Correcting this asymmetry leads to bias-free atrophy estimation.
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DOI：
10.1023/b:visi.0000043755.93987.aa
发表时间：
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影响因子：
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