Population genomic analyses of schistosome parasites highlight critical challenges facing endgame elimination efforts.
Population genomic analyses of schistosome parasites highlight critical challenges facing endgame elimination efforts.
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DOI：
10.1038/s41598-021-86287-y
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发表时间：
2021-03-25
影响因子：
4.6
通讯作者：
Pollock DD
中科院分区：
文献类型：
--
作者：
Shortt JA;Timm LE;Hales NR;Nikolakis ZL;Schield DR;Perry BW;Liu Y;Zhong B;Castoe TA;Carlton EJ;Pollock DD
尽管采取了积极的消灭措施，亚洲地区的血吸虫病仍然存在。为了确定使寄生虫持续传播的因素，我们对多年来从中国四川省传播热点收集的日本血吸虫毛蚴进行了简化代表性基因组测序。我们发现了强大的地理结构，这表明当地而不是进口水库是该地区持续感染的关键来源。在村庄一级，转诊接受吡喹酮治疗后收集的寄生虫与当地治疗前人口密切相关。村庄内的血吸虫也是高度相关的，这表明只有来自有限数量宿主的少数寄生虫才能驱动再感染。来自不同人类宿主的毛蚴之间的密切家族关系也暗示了人类之间的短传播途径。在个体宿主水平上，遗传证据表明，多人在转诊治疗后保留了感染。我们的研究结果表明，最终的血吸虫病控制措施应集中在彻底根除当地的寄生虫水库，并确认成功治疗受感染的人类宿主。
Schistosomiasis persists in Asian regions despite aggressive elimination measures. To identify factors enabling continued parasite transmission, we performed reduced representation genome sequencing on Schistosoma japonicum miracidia collected across multiple years from transmission hotspots in Sichuan, China. We discovered strong geographic structure, suggesting that local, rather than imported, reservoirs are key sources of persistent infections in the region. At the village level, parasites collected after referral for praziquantel treatment are closely related to local pre-treatment populations. Schistosomes within villages are also highly related, suggesting that only a few parasites from a limited number of hosts drive re-infection. The close familial relationships among miracidia from different human hosts also implicate short transmission routes among humans. At the individual host level, genetic evidence indicates that multiple humans retained infections following referral for treatment. Our findings suggest that end-game schistosomiasis control measures should focus on completely extirpating local parasite reservoirs and confirming successful treatment of infected human hosts.
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影响因子：
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通讯作者：
Anderson RM
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使用下一代 DNA 测序数据进行变异发现和基因分型的框架。
影响因子：
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作者：
通讯作者：
--
影响因子：
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作者：
Liu Y;Zhong B;Wu ZS;Liang S;Qiu DC;Ma X
通讯作者：
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影响因子：
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作者：
Jombart, Thibaut;Ahmed, Ismail
通讯作者：
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