Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies.
Influence of type 2 diabetes on brain volumes and changes in brain volumes: results from the Women's Health Initiative Magnetic Resonance Imaging studies.
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DOI：
10.2337/dc12-0555
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发表时间：
2013-01
期刊：
影响因子：
16.2
通讯作者：
WHIMS-MRI Study Group
中科院分区：
文献类型：
--
作者：
Espeland MA;Bryan RN;Goveas JS;Robinson JG;Siddiqui MS;Liu S;Hogan PE;Casanova R;Coker LH;Yaffe K;Masaki K;Rossom R;Resnick SM;WHIMS-MRI Study Group
研究2型糖尿病如何对脑体积、体积变化和认知功能产生不利影响。用结构脑磁共振成像(MRI)测量了1,366名72~89岁女性的局部脑体积和缺血灶体积。698名女性平均在4.7年后进行了重复扫描。比较了患有和不患有糖尿病的女性之间的横断面差异和随时间的变化。研究了认知功能测试分数与这些指标和糖尿病的关系。接受第一次MRI检查的145名糖尿病女性(10.6%)的总脑体积(减少0.6%；P=0.05)和灰质体积(减少1.5%；P=0.01)较小，但总体和主要脑叶内的白质体积没有变化。他们也有更大的缺血损伤体积(21.8%；P=0.02)，总体和灰质(27.5%；P=0.06)，白质(18.8%；P=0.02)，以及跨主叶。总体而言，与未患糖尿病的女性相比，患有糖尿病的女性有轻微(不显著)的总脑体积损失(3.02cc；P=0.11)和显著增加的总缺血损伤体积(增加9.7%；P=0.05)。糖尿病与整体认知功能及其亚域得分较低有关。这些相对缺陷只能部分解释大脑体积和认知缺陷的风险因素。糖尿病与灰质而不是白质的脑体积较小有关，而与整个大脑的缺血病变体积增加有关。这些标记物与糖尿病相关的认知功能障碍有关，但不能完全解释。
To study how type 2 diabetes adversely affects brain volumes, changes in volume, and cognitive function. Regional brain volumes and ischemic lesion volumes in 1,366 women, aged 72–89 years, were measured with structural brain magnetic resonance imaging (MRI). Repeat scans were collected an average of 4.7 years later in 698 women. Cross-sectional differences and changes with time between women with and without diabetes were compared. Relationships that cognitive function test scores had with these measures and diabetes were examined. The 145 women with diabetes (10.6%) at the first MRI had smaller total brain volumes (0.6% less; P = 0.05) and smaller gray matter volumes (1.5% less; P = 0.01) but not white matter volumes, both overall and within major lobes. They also had larger ischemic lesion volumes (21.8% greater; P = 0.02), both overall and in gray matter (27.5% greater; P = 0.06), in white matter (18.8% greater; P = 0.02), and across major lobes. Overall, women with diabetes had slightly (nonsignificant) greater loss of total brain volumes (3.02 cc; P = 0.11) and significant increases in total ischemic lesion volumes (9.7% more; P = 0.05) with time relative to those without diabetes. Diabetes was associated with lower scores in global cognitive function and its subdomains. These relative deficits were only partially accounted for by brain volumes and risk factors for cognitive deficits. Diabetes is associated with smaller brain volumes in gray but not white matter and increasing ischemic lesion volumes throughout the brain. These markers are associated with but do not fully account for diabetes-related deficits in cognitive function.
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影响因子：
--
作者：
Craft, Suzanne;Baker, Laura D.;Montine, Thomas J.;Minoshima, Satoshi;Watson, G. Stennis;Claxton, Amy;Arbuckle, Matthew;Callaghan, Maureen;Tsai, Elaine;Plymate, Stephen R.;Green, Pattie S.;Leverenz, James;Cross, Donna;Gerton, Brooke
通讯作者：
Gerton, Brooke
影响因子：
2.9
作者：
Bruehl H;Wolf OT;Sweat V;Tirsi A;Richardson S;Convit A
通讯作者：
Convit A
影响因子：
16.2
作者：
de Bresser J;Tiehuis AM;van den Berg E;Reijmer YD;Jongen C;Kappelle LJ;Mali WP;Viergever MA;Biessels GJ;Utrecht Diabetic Encephalopathy Study Group
通讯作者：
Utrecht Diabetic Encephalopathy Study Group
影响因子：
4.8
作者：
Jaramillo, Sarah A.;Felton, Deborah;Espeland, Mark A.
通讯作者：
Espeland, Mark A.
影响因子：
2.4
作者：
Gold, Michael;Alderton, Claire;Sawchak, Sharon
通讯作者：
Sawchak, Sharon