Nonmotor symptoms and Parkinson disease in United States farmers and spouses.
Nonmotor symptoms and Parkinson disease in United States farmers and spouses.
复制标题
DOI：
10.1371/journal.pone.0185510
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Shrestha S;Kamel F;Umbach DM;Beane Freeman LE;Koutros S;Alavanja M;Sandler DP;Chen H
很少有研究评估多种非运动症状（NMS）与帕金森病（PD）的关系。因此，我们在《农业健康研究》中研究了个体和多重NMS与PD之间的横断面关联。在2013-2015年的随访调查中，20,473名男性农民和16,259名女性配偶提供了六种NMS（嗅觉减退、做梦行为、白天嗜睡、排便次数少、抑郁和焦虑）的信息。191名男性和68名女性报告了医生诊断的PD。我们使用多变量逻辑回归模型分别按性别估计比值比（ORs）和95%置信区间（CIs）。NMS都与PD相关，其中男性嗅觉减退和女性梦境行为的关联性最强。NMS的数量与PD表现出强烈的剂量反应关系，特别是在男性中。1例患者的or值为5.5 (95% CI 3.4-8.8)， 2例患者的or值为17 (95% CI 10.4-28.0)，男性3例或以上NMS患者的or值为53.4 (95% CI 33.2-86.1)；女性相应的or分别为4.6 （95% CI 2.3-9.5）、6.7 （95% CI 2.9-15.6）和23.6 (95% CI 10.7-52.4) （pnms -交互作用-性别= 0.07）。NMS的数量与PD呈剂量-反应关系，且男性的相关性强于女性。这些发现应该在基于人群的前瞻性研究中进一步研究。
Few studies have evaluated the presence of multiple nonmotor symptoms (NMS) in relation to Parkinson disease (PD). Therefore, we examined cross-sectional associations between individual and multiple NMS and PD in the Agricultural Health Study. 20,473 male farmers and 16,259 female spouses provided information on six NMS (reduced sense of smell, dream-enacting behavior, daytime sleepiness, infrequent bowel movement, depression, and anxiety) in the cohort’s 2013–2015 follow-up survey. 191 men and 68 women reported physician-diagnosed PD. We estimated odds ratios (ORs) and 95% confidence intervals (CIs) using multivariable logistic regression models separately by sex. NMS were each associated with PD, with the strongest association for reduced sense of smell in men and dream-enacting behavior in women. The number of NMS showed a strong dose-response relationship with PD, particularly in men. ORs were 5.5 (95% CI 3.4–8.8) for one, 17 (95% CI 10.4–28.0) for two, and 53.4 (95% CI 33.2–86.1) for three or more NMS in men; the corresponding ORs were 4.6 (95% CI 2.3–9.5), 6.7 (95% CI 2.9–15.6), and 23.6 (95% CI 10.7–52.4) in women (PNMS-interaction-with-sex = 0.07). The number of NMS was associated with PD in a dose-response manner and the association appeared stronger in men than in women. These findings should be further investigated in population-based prospective studies.
登录
查看更多内容
影响因子：
12.6
作者：
Chen H;Zhao EJ;Zhang W;Lu Y;Liu R;Huang X;Ciesielski-Jones AJ;Justice MA;Cousins DS;Peddada S
通讯作者：
Peddada S
影响因子：
120.7
作者：
Murphy, C;Schubert, CR;Nondahl, DM
通讯作者：
Nondahl, DM
影响因子：
5
作者：
Gao, Jianjun;Huang, Xuemei;Chen, Honglei
通讯作者：
Chen, Honglei
影响因子：
6
作者：
Martinez-Martin, Pablo;Pecurariu, Cristian Falup;Chaudhuri, Kallol Ray
通讯作者：
Chaudhuri, Kallol Ray
影响因子：
8.6
作者：
Duncan, Gordon W.;Khoo, Tien K.;Burn, David J.
通讯作者：
Burn, David J.