Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition.
Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition.
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DOI：
10.1021/jf101873f
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发表时间：
2010-09-08
影响因子：
6.1
通讯作者：
Funk JL
中科院分区：
文献类型：
--
作者：
Wright LE;Frye JB;Timmermann BN;Funk JL
从含有生物活性酚类姜黄素的姜黄（Curcuma longa L.，[Zingiberaceae]）制备的提取物在绝经后骨质疏松症性腺功能减退大鼠模型中评估其骨保护作用。三个月雌性 Sprague Dawley 大鼠被切除卵巢 (OVX)，并用化学复合姜黄组分（按重量计 41% 类姜黄素）或富含类姜黄素的姜黄组分（按重量计 94% 类姜黄素）治疗，两者剂量均为 60mg/kg，每周 3 次，或单独使用载体。通过使用双能 X 射线吸收测定法 (DXA) 对股骨远端骨矿物质密度 (BMD) 进行连续评估，前瞻性地跟踪治疗两个月对 OVX 引起的骨质流失的影响，同时通过微型计算机断层扫描 (μCT) 评估两个月后对骨小梁微结构的治疗效果。化学复杂的姜黄并不能阻止骨质流失，然而，富含类姜黄素的姜黄可以阻止多达 50% 的 OVX 引起的骨小梁流失，并且还保留了支柱状骨小梁的数量和连通性。这些结果表明姜黄可能具有骨骼保护作用，但提取物成分是一个关键因素。
Extracts prepared from turmeric (Curcuma longa L., [Zingiberaceae]) containing bioactive phenolic curcuminoids were evaluated for bone-protective effects in a hypogonadal rat model of postmenopausal osteoporosis. Three-month female Sprague Dawley rats were ovariectomized (OVX) and treated with a chemically complex turmeric fraction (41% curcuminoids by weight) or a curcuminoid-enriched turmeric fraction (94% curcuminoids by weight), both dosed at 60mg/kg 3x per week, or vehicle alone. Effects of two months of treatment on OVX-induced bone loss were followed prospectively by serial assessment of bone mineral density (BMD) of the distal femur using dual-energy x-ray absorptiometry (DXA), while treatment effects on trabecular bone microarchitecture were assessed at two months by micro-computerized tomography (μCT). Chemically complex turmeric did not prevent bone loss, however, the curcuminoid-enriched turmeric prevented up to 50% of OVX-induced loss of trabecular bone and also preserved the number and connectedness of the strut-like trabeculae. These results suggest that turmeric may have bone-protective effects but that extract composition is a critical factor.
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影响因子：
7.3
作者：
Chang W;Tu C;Chen TH;Bikle D;Shoback D
通讯作者：
Shoback D
影响因子：
10.4
作者：
Fabricant, DS;Farnsworth, NR
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3.8
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通讯作者：
WAKELING, AE
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作者：
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Phipps, RJ
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作者：
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