Flattened Structural Network Changes and Association of Hyperconnectivity With Symptom Severity in 2-7-Year-Old Children With Autism.
Flattened Structural Network Changes and Association of Hyperconnectivity With Symptom Severity in 2-7-Year-Old Children With Autism.
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DOI：
10.3389/fnins.2021.757838
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发表时间：
2021
影响因子：
4.3
通讯作者：
Huang H
中科院分区：
文献类型：
--
作者：
Ouyang M;Peng Y;Sotardi S;Hu D;Zhu T;Cheng H;Huang H
了解自闭症谱系障碍 (ASD) 的最早诊断年龄时存在的大脑差异对于描述该疾病的潜在神经病理学至关重要。然而，对于自闭症谱系障碍（ASD）儿童2至7岁早期重要发育时期大脑结构网络变化的了解还很有限。在这项研究中，我们旨在通过描述 2 至 7 岁 ASD 中与年龄相关的大脑结构网络变化来填补知识空白，并确定与症状严重程度显着相关的基于网络的敏感成像生物标志物。对 30 名 ASD 儿童和 21 名典型发育 (TD) 儿童进行了弥散 MRI 检查。通过扩散 MRI 和量化临床评估，我们进行了基于网络的分析以及基于图论的测量与症状严重程度之间的相关性。在 2-7 岁的发育阶段，全球网络测量和节点效率存在显着的年龄组交互作用。与 TD 中结构网络与年龄相关的显着增长相比，ASD 中观察到相对平坦的成熟趋势。在自闭症儿童中观察到结构网络中的超连接性具有更高的全局效率、全局网络强度和节点效率。自闭症谱系障碍中的网络边缘强度还证明了广泛的解剖连接中的超连接性，包括默认模式、额顶叶和感觉运动网络中的连接。重要的是，较高的节点效率和较高的网络边缘强度与 ASD 症状严重程度显着相关。总体而言，自闭症谱系障碍 (ASD) 在 2-7 岁的早期发育阶段的结构网络具有超连接性和较慢成熟的特点，异常的超连接性与症状严重程度显着相关。这些异常的网络测量可以作为 2 至 7 岁 ASD 的影像生物标志物。
Understanding the brain differences present at the earliest possible diagnostic age for autism spectrum disorder (ASD) is crucial for delineating the underlying neuropathology of the disorder. However, knowledge of brain structural network changes in the early important developmental period between 2 and 7 years of age is limited in children with ASD. In this study, we aimed to fill the knowledge gap by characterizing age-related brain structural network changes in ASD from 2 to 7 years of age, and identify sensitive network-based imaging biomarkers that are significantly correlated with the symptom severity. Diffusion MRI was acquired in 30 children with ASD and 21 typically developmental (TD) children. With diffusion MRI and quantified clinical assessment, we conducted network-based analysis and correlation between graph-theory-based measurements and symptom severity. Significant age-by-group interaction was found in global network measures and nodal efficiencies during the developmental period of 2–7 years old. Compared with significant age-related growth of the structural network in TD, relatively flattened maturational trends were observed in ASD. Hyper-connectivity in the structural network with higher global efficiency, global network strength, and nodal efficiency were observed in children with ASD. Network edge strength in ASD also demonstrated hyper-connectivity in widespread anatomical connections, including those in default-mode, frontoparietal, and sensorimotor networks. Importantly, identified higher nodal efficiencies and higher network edge strengths were significantly correlated with symptom severity in ASD. Collectively, structural networks in ASD during this early developmental period of 2–7 years of age are characterized by hyper-connectivity and slower maturation, with aberrant hyper-connectivity significantly correlated with symptom severity. These aberrant network measures may serve as imaging biomarkers for ASD from 2 to 7 years of age.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
DOI：
10.1111/j.1469-7610.2006.01531.x
发表时间：
2006-06-01
影响因子：
7.6
作者：
Landa, Rebecca;Garrett-Mayer, Elizabeth
通讯作者：
Garrett-Mayer, Elizabeth
影响因子：
11
作者：
Di Martino, A.;Yan, C-G;Li, Q.;Denio, E.;Castellanos, F. X.;Alaerts, K.;Anderson, J. S.;Assaf, M.;Bookheimer, S. Y.;Dapretto, M.;Deen, B.;Delmonte, S.;Dinstein, I.;Ertl-Wagner, B.;Fair, D. A.;Gallagher, L.;Kennedy, D. P.;Keown, C. L.;Keysers, C.;Lainhart, J. E.;Lord, C.;Luna, B.;Menon, V.;Minshew, N. J.;Monk, C. S.;Mueller, S.;Mueller, R. A.;Nebel, M. B.;Nigg, J. T.;O'Hearn, K.;Pelphrey, K. A.;Peltier, S. J.;Rudie, J. D.;Sunaert, S.;Thioux, M.;Tyszka, J. M.;Uddin, L. Q.;Verhoeven, J. S.;Wenderoth, N.;Wiggins, J. L.;Mostofsky, S. H.;Milham, M. P.
通讯作者：
Milham, M. P.
DOI：
10.1093/brain/awu132
发表时间：
2014-08
期刊：
Brain : a journal of neurology
影响因子：
--
作者：
Crossley NA;Mechelli A;Scott J;Carletti F;Fox PT;McGuire P;Bullmore ET
通讯作者：
Bullmore ET
DOI：
10.1177/1073858414525995
发表时间：
2014-12
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Cole MW;Repovš G;Anticevic A
通讯作者：
Anticevic A