Circadian rhythm profiles in women with night eating syndrome.
Circadian rhythm profiles in women with night eating syndrome.
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夜间饮食综合症女性的昼夜节律概况。
DOI：
10.1177/0748730408328914
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发表时间：
2009-02
影响因子：
3.5
通讯作者：
Dinges DF
中科院分区：
文献类型：
--
作者：
Goel N;Stunkard AJ;Rogers NL;Van Dongen HP;Allison KC;O'Reardon JP;Ahima RS;Cummings DE;Heo M;Dinges DF
夜间进食综合征(NES)的特征是夜间吞噬功能亢进和频繁觉醒，并伴有食物摄入。NES患者表现出延迟的食物摄入昼夜节律模式，但保持正常的睡眠-觉醒周期。这些特征启动了本研究，在该研究中，评估了NES患者行为和神经内分泌昼夜节律的相位和幅度。15名NES患者(平均年龄40.8±8.7岁)和14名对照组(38.6±9.5岁)在实验室进行了为期3晚的研究，每天测量食物摄入量。采血25h(0800~2000h每2h采一次血，2100~0900h每小时采血一次)，测定血糖和7种激素(胰岛素、胃促生长素、瘦素、褪黑素、皮质醇、促甲状腺激素、催乳素)。统计分析采用线性混合效应协方差分析。对照组受试者显示了所有昼夜节律的正常相位和幅度。相比之下，NES患者表现出进餐时间的相位性延迟，以及总热量、脂肪和碳水化合物摄入量的昼夜节律延迟。此外，在两个食物调节节律--瘦素和胰岛素--以及昼夜褪黑激素节律(有昼夜皮质醇节律延迟的趋势)中，发现了1.0至2.8h的相位延迟。相比之下，刺激食物摄入的主要激素Ghrelin的循环水平提前了5.2h。葡萄糖节律显示出倒置的昼夜节律。NES患者的摄食量、皮质醇、Ghrelin和胰岛素的昼夜节律的幅度也降低，但TSH幅度增加。因此，NES患者表现出与食欲和神经内分泌调节有关的各种行为和生理昼夜节律标记物的时间和幅度的显著变化。因此，NES可能是由于中枢(视交叉上核)计时机制和中枢神经系统或外周其他部位(如胃或肝脏)假定的振荡器之间的分离造成的。考虑到这些结果，NES的时间生物学治疗，如强光疗法，可能是有用的。事实上，在病例研究中，强光疗法在减少夜间进食方面显示出了有效性，应该在对照临床试验中进行评估。
Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings accompanied by food intake. Patients with NES display a delayed circadian pattern of food intake but retain a normal sleep-wake cycle. These characteristics initiated the current study, in which the phase and amplitude of behavioral and neuroendocrine circadian rhythms in patients with NES were evaluated. Fifteen women with NES (mean age ± SD, 40.8 ± 8.7 y) and 14 control subjects (38.6 ± 9.5 y) were studied in the laboratory for 3 nights, with food intake measured daily. Blood also was collected for 25 h (every 2 h from 0800 to 2000 h, and then hourly from 2100 to 0900 h) and assayed for glucose and 7 hormones (insulin, ghrelin, leptin, melatonin, cortisol, thyroid-stimulating hormone [TSH] and prolactin). Statistical analyses utilized linear mixed-effects cosinor analysis. Control subjects displayed normal phases and amplitudes for all circadian rhythms. In contrast, patients with NES showed a phase delay in the timing of meals, and delayed circadian rhythms for total caloric, fat, and carbohydrate intake. In addition, phase delays of 1.0 to 2.8 h were found in 2 food-regulatory rhythms—leptin and insulin—and in the circadian melatonin rhythm (with a trend for a delay in the circadian cortisol rhythm). In contrast, circulating levels of ghrelin, the primary hormone that stimulates food intake, were phase advanced by 5.2 h. The glucose rhythm showed an inverted circadian pattern. Patients with NES also showed reduced amplitudes in the circadian rhythms of food intake, cortisol, ghrelin, and insulin, but increased TSH amplitude. Thus, patients with NES demonstrated significant changes in the timing and amplitude of various behavioral and physiological circadian markers involved in appetite and neuroendocrine regulation. As such, NES may result from dissociations between central (suprachiasmatic nucleus) timing mechanisms and putative oscillators elsewhere in the central nervous system or periphery, such as the stomach or liver. Considering these results, chronobiologic treatments for NES such as bright light therapy may be useful. Indeed, bright light therapy has shown efficacy in reducing night eating in case studies and should be evaluated in controlled clinical trials.
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影响因子：
5.8
作者：
Allison, KC;Ahima, RS;Stunkard, AJ
通讯作者：
Stunkard, AJ
影响因子：
5.8
作者：
Bergendahl, M;Iranmanesh, A;Veldhuis, JD
通讯作者：
Veldhuis, JD
影响因子：
5.8
作者：
Mantzoros, CS;Ozata, M;Licinio, J
通讯作者：
Licinio, J
影响因子：
2
作者：
Mikulich, SK;Zerbe, GO;Crowley, TJ
通讯作者：
Crowley, TJ
影响因子：
3.5
作者：
Mühlbauer, E;Wolgast, S;Peschke, E
通讯作者：
Peschke, E