Implications of memory modulation for post-traumatic stress and fear disorders.
Implications of memory modulation for post-traumatic stress and fear disorders.
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DOI：
10.1038/nn.3296
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发表时间：
2013-02
影响因子：
25
通讯作者：
Ressler, Kerry J.
中科院分区：
文献类型：
--
作者：
Parsons, Ryan G.;Ressler, Kerry J.
创伤后应激障碍、恐慌症和恐惧症的表现方式与无法控制的恐惧状态一致。它们的发展涉及遗传、先前的敏感经历、厌恶事件与先前的中性刺激的关联，以及在慢性和致残后无法抑制或消除恐惧。我们强调了恐惧学习和记忆的最新进展，对恐惧障碍的不同易感性，以及如何将这些发现应用于理解，治疗和可能的预防恐惧障碍。有希望的进展正在从基础科学转化为临床，包括创伤暴露前区分风险与恢复力的方法，创伤后记忆巩固期间干扰恐惧发展的方法，以及抑制恐惧再巩固和增强慢性恐惧消退的技术。希望这些新知识将转化为更成功的，神经科学的知情和合理设计的方法来治疗恐惧调节障碍。
Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are consistent with an uncontrollable state of fear. Their development involves heredity, previous sensitizing experiences, association of aversive events with previous neutral stimuli, and inability to inhibit or extinguish fear after it is chronic and disabling. We highlight recent progress in fear learning and memory, differential susceptibility to disorders of fear, and how these findings are being applied to the understanding, treatment and possible prevention of fear disorders. Promising advances are being translated from basic science to the clinic, including approaches to distinguish risk versus resilience before trauma exposure, methods to interfere with fear development during memory consolidation after a trauma, and techniques to inhibit fear reconsolidation and to enhance extinction of chronic fear. It is hoped that this new knowledge will translate to more successful, neuroscientifically informed and rationally designed approaches to disorders of fear regulation.
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DOI：
10.1111/j.1601-183x.2012.00801.x
发表时间：
2012-07
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Andero R;Ressler KJ
通讯作者：
Ressler KJ
影响因子：
64.8
作者：
Ciocchi, Stephane;Herry, Cyril;Luethi, Andreas
通讯作者：
Luethi, Andreas
影响因子：
56.9
作者：
BECHARA, A;TRANEL, D;DAMASIO, AR
通讯作者：
DAMASIO, AR
影响因子：
3.6
作者：
Carrion, Victor G.;Haas, Brian W.;Reiss, Allan L.
通讯作者：
Reiss, Allan L.
影响因子：
120.7
作者：
Binder, Elisabeth B.;Bradley, Rebekah G.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.