Cholinergic centro-cingulate network in Parkinson disease and normal aging.
Cholinergic centro-cingulate network in Parkinson disease and normal aging.
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DOI：
10.18632/aging.205209
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发表时间：
2023-10-27
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影响因子：
--
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最近发现的中央扣带回大脑网络中胆碱能结合的减少已被证明与帕金森病（PD）认知障碍的严重程度密切相关。该网络在扣带回、鳃盖和中央周围皮质区域内具有关键枢纽，也与帕金森病运动障碍的因素相关，包括姿势不稳定和步态困难，例如跌倒或冻结。 MRI 神经影像研究表明，前中扣带皮层是运动产生认知方面（即有意运动控制）的关键节点。最近的证据还表明初级运动皮层组织的一个新颖方面，描述了用于精细运动控制的“效应器”区域，其中插入了用于全身控制的相互关联的“效应器间”区域。效应器间区域的一个显着特征是与扣带区和鳃盖区紧密相连。这种效应器间区域被认为是整合目标和运动所必需的更大的躯体认知行动网络的一部分。最近的证据还表明，非帕金森病老年人的中央扣带回网络中的胆碱能神经末梢存在脆弱性。正常衰老的这些特征强调，与年龄相关的神经退行性疾病中的皮质胆碱能末端损失可能不仅是疾病特异性病因的结果，而且还与其他正常衰老有关。这种重叠的实际意义是，解决与神经退行性变有关的疾病特异性和一般衰老病因，可能对存在显着胆碱能系统退行性的年龄相关神经退行性疾病有益。
Decreased cholinergic binding within the recently identified centro-cingulate brain network robustly has been shown to robustly correlate with the severity of cognitive impairment in Parkinson disease (PD). This network with key hubs within the cingulum, operculum and peri-central cortical regions also correlates with elements of parkinsonian motor impairments, including postural instability and gait difficulties, such as falls or freezing. MRI neuroimaging studies have shown that the anterior midcingulate cortex is a key node for cognitive aspects of movement generation, i.e., intentional motor control. Recent evidence also suggests a novel aspect of organization of primary motor cortex, describing “effector” regions for fine movement control intercalated with interlinked “inter-effector” regions devoted to whole-body control. A distinguishing feature of inter-effector regions is tight linkage to the cingular and opercular regions. Such inter-effector regions have been proposed to be part of a greater somato-cognitive action network necessary for integration of goals and movement. Recent evidence also points to vulnerabilities of cholinergic nerve terminals in the centro-cingulate network in older non-PD adults. These features of normal aging underscore that cortical cholinergic terminal losses in age-associated neurodegenerative disorders are likely not exclusively the result of disease-specific etiologies but also related to otherwise normal aging. Practical implications of this overlap are that addressing disease-specific and general aging etiologies involved in neurodegeneration, may be of benefit in age-associated neurodegenerative disorders where significant cholinergic systems degeneration is present.
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影响因子：
11.2
作者：
Bohnen, Nicolaas, I;Kanel, Prabesh;Mueller, Martijn L. T. M.
通讯作者：
Mueller, Martijn L. T. M.
影响因子：
64.8
作者：
Gordon, Evan M.;Chauvin, Roselyne J.;Van, Andrew N.;Rajesh, Aishwarya;Nielsen, Ashley;Newbold, Dillan J.;Lynch, Charles J.;Seider, Nicole A.;Krimmel, Samuel R.;Scheidter, Kristen M.;Monk, Julia;Miller, Ryland L.;Metoki, Athanasia;Montez, David F.;Zheng, Annie;Elbau, Immanuel;Madison, Thomas;Nishino, Tomoyuki;Myers, Michael J.;Kaplan, Sydney;D'Andrea, Carolina Badke;Demeter, Damion V.;Feigelis, Matthew;Ramirez, Julian S. B.;Xu, Ting;Barch, Deanna M.;Smyser, Christopher D.;Rogers, Cynthia E.;Zimmermann, Jan;Botteron, Kelly N.;Pruett, John R.;Willie, Jon T.;Brunner, Peter;Shimony, Joshua S.;Kay, Benjamin P.;Marek, Scott;Norris, Scott A.;Gratton, Caterina;Sylvester, Chad M.;Power, Jonathan D.;Liston, Conor;Greene, Deanna J.;Roland, Jarod L.;Petersen, Steven E.;Raichle, Marcus E.;Laumann, Timothy O.;Fair, Damien A.;Dosenbach, Nico U. F.
通讯作者：
Dosenbach, Nico U. F.
影响因子：
4.8
作者：
通讯作者：
--
影响因子：
4.8
作者：
Bohnen NI;Kanel P;Koeppe RA;Sanchez-Catasus CA;Frey KA;Scott P;Constantine GM;Albin RL;Müller MLTM
通讯作者：
Müller MLTM
影响因子：
4.8
作者：
Hoffstaedter F;Grefkes C;Caspers S;Roski C;Palomero-Gallagher N;Laird AR;Fox PT;Eickhoff SB
通讯作者：
Eickhoff SB