A somato-cognitive action network alternates with effector regions in motor cortex.
A somato-cognitive action network alternates with effector regions in motor cortex.
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DOI：
10.1038/s41586-023-05964-2
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发表时间：
2023-05
期刊：
影响因子：
64.8
通讯作者：
Dosenbach, Nico U. F.
中科院分区：
文献类型：
--
作者：
Gordon, Evan M.;Chauvin, Roselyne J.;Van, Andrew N.;Rajesh, Aishwarya;Nielsen, Ashley;Newbold, Dillan J.;Lynch, Charles J.;Seider, Nicole A.;Krimmel, Samuel R.;Scheidter, Kristen M.;Monk, Julia;Miller, Ryland L.;Metoki, Athanasia;Montez, David F.;Zheng, Annie;Elbau, Immanuel;Madison, Thomas;Nishino, Tomoyuki;Myers, Michael J.;Kaplan, Sydney;D'Andrea, Carolina Badke;Demeter, Damion V.;Feigelis, Matthew;Ramirez, Julian S. B.;Xu, Ting;Barch, Deanna M.;Smyser, Christopher D.;Rogers, Cynthia E.;Zimmermann, Jan;Botteron, Kelly N.;Pruett, John R.;Willie, Jon T.;Brunner, Peter;Shimony, Joshua S.;Kay, Benjamin P.;Marek, Scott;Norris, Scott A.;Gratton, Caterina;Sylvester, Chad M.;Power, Jonathan D.;Liston, Conor;Greene, Deanna J.;Roland, Jarod L.;Petersen, Steven E.;Raichle, Marcus E.;Laumann, Timothy O.;Fair, Damien A.;Dosenbach, Nico U. F.
运动皮层（M1）被认为形成了一个连续的躯体定位的侏儒，从脚到脸的中央前回延伸，尽管有证据表明同心功能区和复杂行动的地图。在这里，使用精确的功能磁共振成像（fMRI）方法，我们发现经典的侏儒被具有不同连接性，结构和功能的区域打断，与效应器特异性（脚，手和嘴）区域交替。这些效应器间区域表现出减少的皮质厚度和彼此之间以及与扣带回-盖神经网络（CON）的强功能连接，这对于动作和生理控制、唤醒、错误和疼痛至关重要。动作控制相关区域和运动效应器区域的这种交错在三个最大的fMRI数据集中得到了验证。猕猴和小儿（新生儿，婴儿和儿童）的精确功能磁共振成像表明跨物种的同源物和发展的前体的相互效应系统。电池的电机和动作功能磁共振成像任务记录同心效应器somatotopies，分开的CON连接的效应器间的区域。交互效应器缺乏运动特异性，并且在动作规划（手和脚的协调）和轴向身体运动（例如腹部或眉毛）期间被共同激活。这些结果，以及先前的研究表明刺激诱发的复杂动作和与肾上腺髓质等内脏器官的连接，表明M1被全身动作规划系统，即躯体认知动作网络（SCAN）打断。在M1中，两个平行的系统相互交错，形成一个整合-隔离模式：效应器特定区域（脚，手和嘴）用于隔离精细运动控制，SCAN用于整合目标，生理和身体运动。不同年龄段的功能性磁共振成像研究表明，人类运动皮层的经典侏儒实际上是不连续的，与称为躯体认知动作网络的动作控制相关区域交替出现。
Motor cortex (M1) has been thought to form a continuous somatotopic homunculus extending down the precentral gyrus from foot to face representations, despite evidence for concentric functional zones and maps of complex actions. Here, using precision functional magnetic resonance imaging (fMRI) methods, we find that the classic homunculus is interrupted by regions with distinct connectivity, structure and function, alternating with effector-specific (foot, hand and mouth) areas. These inter-effector regions exhibit decreased cortical thickness and strong functional connectivity to each other, as well as to the cingulo-opercular network (CON), critical for action and physiological control, arousal, errors and pain. This interdigitation of action control-linked and motor effector regions was verified in the three largest fMRI datasets. Macaque and pediatric (newborn, infant and child) precision fMRI suggested cross-species homologues and developmental precursors of the inter-effector system. A battery of motor and action fMRI tasks documented concentric effector somatotopies, separated by the CON-linked inter-effector regions. The inter-effectors lacked movement specificity and co-activated during action planning (coordination of hands and feet) and axial body movement (such as of the abdomen or eyebrows). These results, together with previous studies demonstrating stimulation-evoked complex actions and connectivity to internal organs such as the adrenal medulla, suggest that M1 is punctuated by a system for whole-body action planning, the somato-cognitive action network (SCAN). In M1, two parallel systems intertwine, forming an integrate–isolate pattern: effector-specific regions (foot, hand and mouth) for isolating fine motor control and the SCAN for integrating goals, physiology and body movement. Functional MRI studies across ages show that the classic homunculus of the motor cortex in humans is in fact discontinuous, alternating with action control-linked regions termed the somato-cognitive action network.
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DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
DOI：
10.1038/nrn3950
发表时间：
2015-07
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Barrett LF;Simmons WK
通讯作者：
Simmons WK
影响因子：
56.9
作者：
Desmurget, Michel;Reilly, Karen T.;Sirigu, Angela
通讯作者：
Sirigu, Angela
DOI：
10.1073/pnas.1605044113
发表时间：
2016-08-30
影响因子：
11.1
作者：
Dum, Richard P.;Levinthal, David J.;Strick, Peter L.
通讯作者：
Strick, Peter L.
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender