Interplay of brain structure and function in neonatal congenital heart disease.
Interplay of brain structure and function in neonatal congenital heart disease.
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DOI：
10.1002/acn3.336
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发表时间：
2016-09
影响因子：
5.3
通讯作者：
Hahn, Cecil D.
中科院分区：
文献类型：
--
作者：
Birca, Ala;Vakorin, Vasily A.;Porayette, Prashob;Madathil, Sujana;Chau, Vann;Seed, Mike;Doesburg, Sam M.;Blaser, Susan;Nita, Dragos A.;Sharma, Rohit;Duerden, Emma G.;Hickey, Edward J.;Miller, Steven P.;Hahn, Cecil D.
通过脑电图连通性分析，评价先天性心脏病（CHD）新生儿脑结构和微结构异常是否与神经网络功能障碍相关。我们研究了20名冠心病新生儿的前瞻性队列，他们术前接受连续脑电图监测来评估脑功能成熟和网络连通性，结构磁共振成像（MRI）来确定脑损伤和脑结构发育的存在，弥散张量MRI来评估脑微结构发育。MRI脑损伤和脑结构和微结构发育延迟的新生儿表现出明显更强的高频（β和γ频段）连通性。此外，大脑微观结构发育迟缓的新生儿表现出明显较弱的低频（δ、θ、α频段）连通性。脑损伤新生儿也表现出脑电背景活动功能成熟延迟，其特征是更大的背景不连续性。这些数据提供了新的证据，表明早期结构和微观结构发育的大脑异常可以产生直接的功能后果，表现为神经元网络连接的特征性改变。这种发育中的神经网络的早期扰动，如果持续下去，可能是青少年冠心病幸存者中普遍存在的持续性神经认知障碍的原因。这些对进化的大脑结构和功能之间复杂相互作用的基本见解可能与广泛的表现为早期发育性脑损伤的神经系统疾病有关。
To evaluate whether structural and microstructural brain abnormalities in neonates with congenital heart disease (CHD) correlate with neuronal network dysfunction measured by analysis of EEG connectivity. We studied a prospective cohort of 20 neonates with CHD who underwent continuous EEG monitoring before surgery to assess functional brain maturation and network connectivity, structural magnetic resonance imaging (MRI) to determine the presence of brain injury and structural brain development, and diffusion tensor MRI to assess brain microstructural development. Neonates with MRI brain injury and delayed structural and microstructural brain development demonstrated significantly stronger high‐frequency (beta and gamma frequency band) connectivity. Furthermore, neonates with delayed microstructural brain development demonstrated significantly weaker low‐frequency (delta, theta, alpha frequency band) connectivity. Neonates with brain injury also displayed delayed functional maturation of EEG background activity, characterized by greater background discontinuity. These data provide new evidence that early structural and microstructural developmental brain abnormalities can have immediate functional consequences that manifest as characteristic alterations of neuronal network connectivity. Such early perturbations of developing neuronal networks, if sustained, may be responsible for the persistent neurocognitive impairment prevalent in adolescent survivors of CHD. These foundational insights into the complex interplay between evolving brain structure and function may have relevance for a wide spectrum of neurological disorders manifesting early developmental brain injury.
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DOI：
10.1016/j.clinph.2014.04.003
发表时间：
2015-01
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Nunez PL;Srinivasan R;Fields RD
通讯作者：
Fields RD
低体温循环停止或低流量心肺旁路心脏手术后儿童的发育和神经状况
影响因子：
158.5
作者：
BELLINGER, DC;JONAS, RA;NEWBURGER, JW
通讯作者：
NEWBURGER, JW
通过局部和长途通信对神经元连接组的神经胶质调节。
影响因子：
16.2
作者：
Fields, R. Douglas;Woo, Dong Ho;Basser, Peter J.
通讯作者：
Basser, Peter J.
影响因子：
37.8
作者：
McQuillen, PS;Hamrick, SEG;Miller, SP
通讯作者：
Miller, SP
影响因子：
4.7
作者：
Gonzalez, Julian J.;Manas, Soledad;Pereda, Ernesto
通讯作者：
Pereda, Ernesto