Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling.
Opioid and Psychostimulant Plasticity: Targeting Overlap in Nucleus Accumbens Glutamate Signaling.
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DOI：
10.1016/j.tips.2017.12.004
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发表时间：
2018-03
影响因子：
13.8
通讯作者：
Thomas MJ
中科院分区：
文献类型：
--
作者：
Hearing M;Graziane N;Dong Y;Thomas MJ
成瘾行为的共性，如渴望，刺激驱动的药物寻求，以及戒断后复发的高倾向，推动了一个涵盖大多数滥用物质的成瘾统一理论。这种统一的理论最近受到了挑战——引用结构神经可塑性、生化信号和神经回路的区别来论证阿片类药物和精神兴奋剂成瘾在行为和神经生物学上是不同的。最近对药物诱导可塑性的更有选择性的研究强调，这两类药物通过改变伏隔核中的兴奋性突触（奖励系统的关键组成部分），促进了整个奖励回路信号的重叠。我们讨论了阿片类药物和精神兴奋剂产生的突触前/突触后和突触外谷氨酸信号的适应，以及它们与电路重塑和成瘾相关行为的相关性，认为这些核心神经适应是开发药物治疗多种药物成瘾的重要靶点。
Commonalities in addictive behavior, such as craving, stimuli-driven drug seeking, and a high propensity for relapse following abstinence, have pushed for a unified theory of addiction that encompasses most abused substances. This unitary theory has recently been challenged -- citing distinctions in structural neural plasticity, biochemical signaling, and neural circuitry to argue that addiction to opioids and psychostimulants are behaviorally and neurobiologically distinct. Recent more selective examination of drug-induced plasticity have highlighted that these two drug classes promote an overall reward circuitry signaling overlap through modifying excitatory synapses in the nucleus accumbens – a key constituent of the reward system. We discuss adaptations in pre-/postsynaptic, and extrasynaptic glutamate signaling produced by opioids and psychostimulants, and their relevance to circuit remodeling and addiction related behavior -- arguing that these core neural adaptations are important targets for developing pharmacotherapies to treat addiction to multiple drugs.
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影响因子：
25
作者：
Bock, Roland;Shin, J. Hoon;Kaplan, Alanna R.;Dobi, Alice;Markey, Eric;Kramer, Paul F.;Gremel, Christina M.;Christensen, Christine H.;Adrover, Martin F.;Alvarez, Veronica A.
通讯作者：
Alvarez, Veronica A.
影响因子：
4.2
作者：
Bajo, M;Crawford, EF;Siggins, GR
通讯作者：
Siggins, GR
影响因子：
16.2
作者：
Bowers, M. Scott;Chen, Billy T.;Bonci, Antonello
通讯作者：
Bonci, Antonello
影响因子：
56.9
作者：
Brebner, K;Wong, TP;Wang, YT
通讯作者：
Wang, YT
DOI：
10.1523/jneurosci.5375-10.2011
发表时间：
2011-02-02
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Dobi A;Seabold GK;Christensen CH;Bock R;Alvarez VA
通讯作者：
Alvarez VA