D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways.
D-pinitol inhibits prostate cancer metastasis through inhibition of αVβ3 integrin by modulating FAK, c-Src and NF-κB pathways.
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DOI：
10.3390/ijms14059790
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发表时间：
2013-05-08
影响因子：
5.6
通讯作者：
Tang CH
中科院分区：
文献类型：
--
作者：
Lin TH;Tan TW;Tsai TH;Chen CC;Hsieh TF;Lee SS;Liu HH;Chen WC;Tang CH
前列腺癌是男性中最常见的恶性肿瘤，并且显示出转移到骨的倾向。松醇是d-手性肌醇的3-甲氧基类似物，被鉴定为大豆食品和豆类中的活性成分，并且已被证明可诱导肿瘤细胞凋亡和癌细胞转移。在这项研究中，我们研究了D-松醇在人前列腺癌细胞中的抗转移作用。我们发现，D-松醇减少前列腺癌细胞（PC 3和DU 145）在非细胞毒性浓度的迁移和侵袭。整合素是哺乳动物细胞中主要的粘附分子，与癌细胞的转移有关。用D-松醇处理前列腺癌细胞减少αvβ3整合素的mRNA和细胞表面表达。此外，D-松醇还通过降低粘着斑激酶（FAK）磷酸化、c-Src激酶活性和NF-κB活化发挥其抑制作用。因此，D-松醇可能是一种新的抗前列腺癌转移药物。
Prostate cancer is the most commonly diagnosed malignancy in men and shows a predilection for metastasis to the bone. D-pinitol, a 3-methoxy analogue of d-chiro-inositol, was identified as an active principle in soy foods and legumes, and it has been proven to induce tumor apoptosis and metastasis of cancer cells. In this study, we investigated the anti-metastasis effects of D-pinitol in human prostate cancer cells. We found that D-pinitol reduced the migration and the invasion of prostate cancer cells (PC3 and DU145) at noncytotoxic concentrations. Integrins are the major adhesive molecules in mammalian cells and have been associated with the metastasis of cancer cells. Treatment of prostate cancer cells with D-pinitol reduced mRNA and cell surface expression of αvβ3 integrin. In addition, D-pinitol exerted its inhibitory effects by reducing focal adhesion kinase (FAK) phosphorylation, c-Src kinase activity and NF-κB activation. Thus, D-pinitol may be a novel anti-metastasis agent for the treatment of prostate cancer metastasis.
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影响因子：
5.6
作者：
Huang, Chih-Yang;Yu, Hsin-Shan;Tang, Chih-Hsin
通讯作者：
Tang, Chih-Hsin
DOI：
10.1073/pnas.0808171105
发表时间：
2008-10-14
影响因子：
11.1
作者：
Boukerche, Habib;Su, Zao-zhong;Fisher, Paul B.
通讯作者：
Fisher, Paul B.
影响因子：
5.8
作者：
Pezzuto, JM
通讯作者：
Pezzuto, JM
影响因子：
3.6
作者：
Gecthan, P. K. M. Anu;Prince, P. Stanely Mainzen
通讯作者：
Prince, P. Stanely Mainzen
影响因子：
6.1
作者：
Fang, SH;Hou, YC;Chiang, BL
通讯作者：
Chiang, BL