Evidence for distinct preterm and term phenotypes of preeclampsia.
Evidence for distinct preterm and term phenotypes of preeclampsia.
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DOI：
10.3109/14767050903258746
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发表时间：
2010-07
期刊：
影响因子：
--
通讯作者：
Bernstein IM
中科院分区：
文献类型：
--
作者：
Phillips JK;Janowiak M;Badger GJ;Bernstein IM
To determine if there are differences in maternal and fetal characteristics in pregnancies complicated by preterm versus term preeclampsia. Using our electronic database we identified 143 women who met the ACOG criteria for preeclampsia between January 1995 and August 2003. We collected data on age, weight, height, smoking status, maternal serum biochemical markers and newborn data. We compared the group delivering preterm (<37 weeks) with those delivering at term (≥37 weeks). Analyses were based on ANOVA, Wilcoxon Rank Sum tests and chi-square tests. Statistical significance was determined based on alpha = .05. Data are expressed as mean ± s.d. unless otherwise indicated. Eighty women delivered preterm and 63 delivered at term. Women who delivered preterm with preeclampsia were younger (age 24.4 ± 4.9 years vs 27.7 ± 6.0 yrs, P<0.001), lighter (BMI 25.8 ± 5.6 vs 28.9 ± 7.3 kg/m2, P=0.01) and were more likely to smoke cigarettes (28% vs 9%, P=0.008) than those delivering at term with preeclampsia. Maternal serum liver enzyme concentrations were significantly greater in the preterm group (peak AST 38 vs 30 U/L, P=0.006), (peak ALT 31 vs 23 U/L, P=0.001). Newborn birth weight percentile (gestational age specific) was significantly lower for preterm preeclampsia (25th ±29 vs 47th ±32 percentile, P<0.001). We found no significant differences in maternal platelet count nadir, peak uric acid concentration, or newborn gender between groups. Differences exist in maternal and fetal characteristics between women who develop preterm preeclampsia and those who develop preeclampsia at term. These data support the hypothesis that multiple preeclamptic phenotypes exist.
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影响因子：
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作者：
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DOI：
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发表时间：
1986-11-01
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通讯作者：
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