MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.
MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.
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DOI：
10.1037/a0016716
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发表时间：
2009-10
影响因子：
1.9
通讯作者：
Yamamoto, Bryan K.
中科院分区：
文献类型：
--
作者：
Cunningham, Jacobi I.;Raudensky, Jamie;Tonkiss, John;Yamamoto, Bryan K.
3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse world-wide and a selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug abuse and relapse is stress. Although multiple parallels exist between MDMA abuse and stress including effects on 5-HTergic neurotransmission, few studies have investigated the consequences of combined exposure to MDMA and chronic stress. Therefore, rats were pretreated with MDMA and exposed 7 days later to 10 days of mild chronic unpredictable stress (CUS). MDMA pretreatment was hypothesized to enhance the effects of CUS leading to enhanced 5-HT transporter (SERT) depletion in the hippocampus and increased anxiety and cognitive impairment. While MDMA alone increased anxiety-like behavior on the elevated plus maze, CUS alone or in combination with MDMA pretreatment did not increase anxiety-like behavior. In contrast, MDMA pretreatment led to CUS-induced learning impairment in the Morris water maze but not an enhanced depletion of hippocampal SERT protein. These results show that prior exposure to MDMA leads to stress-induced impairments in learning behavior that is not otherwise observed with stress alone and appear unrelated to an enhanced depletion of SERT.
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影响因子：
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通讯作者：
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MCEWEN, BS
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Maier, SF