T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes.
T2D-Db: an integrated platform to study the molecular basis of Type 2 diabetes.
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T2D-DB：研究2型糖尿病的分子基础的集成平台。
DOI：
10.1186/1471-2164-9-320
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发表时间：
2008-07-07
期刊：
影响因子：
4.4
通讯作者：
Sengupta U
中科院分区：
文献类型：
--
作者：
Agrawal S;Dimitrova N;Nathan P;Udayakumar K;Lakshmi SS;Sriram S;Manjusha N;Sengupta U
2 型糖尿病 (T2DM) 是一种非胰岛素依赖性、复杂的特征性疾病，由于遗传倾向和环境因素而发生。 2型糖尿病的晚期会导致多种微血管和大血管并发症，如肾病、神经病、视网膜病、心脏相关问题等。为了了解2型糖尿病的病理生理学，对该疾病的遗传学、生物化学和分子生物学进行的研究已经产生了大量关于候选基因和相关方面的数据。该研究在确定这种疾病的确切病因方面取得了很大进展。 T2D-Db（2 型糖尿病数据库）是一个综合性网络资源，提供有关三种广泛研究的哺乳动物（人类、小鼠和大鼠）2 型糖尿病发病机制的几乎所有已知分子成分的综合和精选信息。有关候选基因、候选基因或候选区域中的 SNP（单核苷酸多态性）、全基因组关联研究 (GWA)、组织特异性基因表达模式、EST（表达序列标签）数据、微阵列数据的表达信息、通路、蛋白质-蛋白质相互作用以及疾病相关风险因素或并发症的信息已在此在线资源中构建。 T2D-Db 中提供的信息为更好地在分子水平上了解 2 型糖尿病及其发病机制提供了一个综合平台。重要的是，该资源除了提供来自单个或多个研究的微阵列表达实验中生物体中选定基因的热图之外，还有助于以图形方式呈现 SNP 标记的基因/基因组范围图和蛋白质-蛋白质相互作用网络。这些功能有助于以综合方式解释数据。据我们所知，T2D-Db 是第一个公开可用的资源，可以满足研究 2 型糖尿病不同方面的研究人员的需求。
Type 2 Diabetes Mellitus (T2DM) is a non insulin dependent, complex trait disease that develops due to genetic predisposition and environmental factors. The advanced stage in type 2 diabetes mellitus leads to several micro and macro vascular complications like nephropathy, neuropathy, retinopathy, heart related problems etc. Studies performed on the genetics, biochemistry and molecular biology of this disease to understand the pathophysiology of type 2 diabetes mellitus has led to the generation of a surfeit of data on candidate genes and related aspects. The research is highly progressive towards defining the exact etiology of this disease. T2D-Db (Type 2 diabetes Database) is a comprehensive web resource, which provides integrated and curated information on almost all known molecular components involved in the pathogenesis of type 2 diabetes mellitus in the three widely studied mammals namely human, mouse and rat. Information on candidate genes, SNPs (Single Nucleotide Polymorphism) in candidate genes or candidate regions, genome wide association studies (GWA), tissue specific gene expression patterns, EST (Expressed Sequence Tag) data, expression information from microarray data, pathways, protein-protein interactions and disease associated risk factors or complications have been structured in this on line resource. Information available in T2D-Db provides an integrated platform for the better molecular level understanding of type 2 diabetes mellitus and its pathogenesis. Importantly, the resource facilitates graphical presentation of the gene/genome wide map of SNP markers and protein-protein interaction networks, besides providing the heat map diagram of the selected gene(s) in an organism across microarray expression experiments from either single or multiple studies. These features aid to the data interpretation in an integrative way. T2D-Db is to our knowledge the first publicly available resource that can cater to the needs of researchers working on different aspects of type 2 diabetes mellitus.
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