Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study.
Efficacy and Safety of Single-Session Radiofrequency Ablation in Treating Benign Thyroid Nodules: A Short-Term Prospective Cohort Study.
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DOI：
10.1155/2021/7556393
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发表时间：
2021
影响因子：
2.8
通讯作者：
Le CV
中科院分区：
文献类型：
--
作者：
Nguyen VB;Nguyen TX;Nguyen VVH;Nguyen HT;Nguyen DT;Le CV
本研究的目的是评估射频消融治疗良性甲状腺结节的安全性和有效性，并寻找与结节体积缩小率相关的独立因素。本短期前瞻性研究来自同一医疗中心，对93例接受RFA治疗的93例良性甲状腺结节患者进行了研究。使用了两种基本技术：跨峡入路和移动投篮技术。在治疗后1个月和3个月随访时进行临床和超声检查。主要结局包括随访1个月和3个月时的体积缩小率（VRR）；次要结果为治疗成功率和并发症。采用多元线性回归分析确定与VRR相关的独立因素。78例患者共78个结节，随访3个月，随访率为83.8%（其中实性结节60例，囊性结节16例，甲状腺囊肿2例）。随访1个月和3个月后，平均体积缩小率分别为41.47%和64.72%。1个月治疗成功率为30.8%，3个月治疗成功率为84.6%。症状评分和美容评分均有显著改善。甲状腺功能检查无变化。发现两种轻微并发症（一过性变声）。多元线性回归分析显示，3个月随访期间，结节内部成分与VRR显著相关（β = 23.00; 95%CI(7.59 ~ 38.45)）。RFA是一种安全有效的治疗良性甲状腺结节的方法。它可以作为一种替代治疗方法，效果令人鼓舞。
The aims of this study are to evaluate the safety and efficacy of RFA in the treatment of benign thyroid nodule(s) and to find independent factors related to the volume reduction rate of the nodule(s). This short-term prospective study from a single medical center was conducted on 93 benign thyroid nodules in 93 patients treated with RFA. Two basic techniques were used: the trans-isthmic approach and moving-shot technique. Clinical and ultrasonography examinations were performed at 1- and 3-month follow-up after the treatment session. Primary outcomes included volume reduction ratio (VRR) at 1-month and 3-month follow-ups; secondary outcomes were therapeutic success rate and complications. Multiple linear regression analysis was used to determine independent factors associated with VRR. A final sample of 78 patients with 78 nodules, given participant rate 83.8% (including 60 solid nodules, 16 predominantly cystic nodules, and 2 thyroid cysts), was followed up for 3 months. The mean volume reduction ratio was 41.47% and 64.72% after 1-month and 3-month follow-ups, respectively. The therapeutic success rate was 30.8% at 1-month and 84.6% at 3-month follow-ups. Symptom score and cosmetic score improved significantly. There was no change in thyroid function tests. Two minor complications (transient voice change) were found. The multiple linear regression analysis showed that the internal component of the nodules significantly related to the VRR during the 3-month follow-up (β = 23.00; 95%CI (7.59–38.45)). RFA was demonstrated as a safe and effective option for benign thyroid nodules treatment. It can be used as an alternative treatment with encouraging results.
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DOI：
10.1590/2359-3997000000246
发表时间：
2017-03-01
期刊：
Archives of Endocrinology and Metabolism
影响因子：
--
作者：
Cesareo, Roberto;Palermo, Andrea;Cianni, Roberto
通讯作者：
Cianni, Roberto
影响因子：
2.9
作者：
Deandrea, Maurilio;Limone, Paolo;Garberoglio, Roberto
通讯作者：
Garberoglio, Roberto
影响因子：
4.8
作者：
Jung SL;Baek JH;Lee JH;Shong YK;Sung JY;Kim KS;Lee D;Kim JH;Baek SM;Sim JS;Na DG
通讯作者：
Na DG
影响因子：
19.7
作者：
Baek, Jung Hwan;Lee, Jeong Hyun;Na, Dong Gyu
通讯作者：
Na, Dong Gyu
DOI：
10.1016/j.jvir.2019.04.022
发表时间：
2019-10-01
影响因子：
2.9
作者：
Aldea Martinez, Jesus;Aldea Viana, Laura;Ruiz Perez, Enrique
通讯作者：
Ruiz Perez, Enrique