Sex difference in Onuf's nucleus homologue in the Asian musk shrew.
Sex difference in Onuf's nucleus homologue in the Asian musk shrew.
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DOI：
10.1016/j.brainres.2010.05.056
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发表时间：
2010-07-30
期刊：
影响因子：
2.9
通讯作者：
Freeman LM
中科院分区：
文献类型：
--
作者：
Polak K;Freeman LM
会阴肌肉是交配所必需的，人类的Onuf核和大鼠的球海绵体脊束核(SNB)和背外侧核(DLN)对会阴肌肉有影响。在所研究的大多数物种中，这些结构由于发育中的雄激素暴露而发生性别分化。亚洲麝鼠(Suncus Murinus)的同源结构是位于脊髓腹角外侧DLN/Onuf位置的单一簇，这些运动神经元既支配麝鼠的球状海绵体肌肉，也支配坐骨海绵体肌肉。在DLN中发现了预期的运动神经元数量的性别差异，但在两个相邻的运动神经元簇背外侧核(RDLN)和腹外侧核(VLN)中却没有发现性别差异。雄性麝鼠VLN和DLN的胞体面积也显著大于雌性，雄性DLN运动神经元的核显著大于雌性。DLN运动神经元数量的性别差异在原始计数和考虑分裂核错误后都是明显的。
Perineal muscles essential for copulatory functioning are innvervated by Onuf’s nucleus in humans and the spinal nucleus of the bulbocavernosus (SNB) and dorsolateral nucleus (DLN) in rats. These structures sexually differentiate as a result of developmental androgen exposure in most species examined. The homologous structure in the Asian musk shrew (Suncus murinus) is a single cluster in the lateral DLN/Onuf’s position in the ventral horn of the spinal cord; these motoneurons innervate both the bulbocavernosus and ischiocavernosus muscles of the musk shrew. We found the expected sex difference in motoneuron number in the shrew DLN, but not in two neighboring motoneuron clusters, the retrodorsolateral nucleus (RDLN) and ventrolateral nucleus (VLN). Male musk shrews also have significantly larger soma areas in the VLN and DLN than females, and male DLN motoneurons have significantly larger nuclei than female. The sex difference in DLN motoneuron number was evident both in raw counts and after accounting for split nuclei error.
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影响因子：
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作者：
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