Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability.
Chronic alcohol self-administration in monkeys shows long-term quantity/frequency categorical stability.
复制标题
猴子中的慢性酒精自我给药显示长期数量/频率分类稳定性。
DOI：
10.1111/acer.12547
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发表时间：
2014-11
期刊：
影响因子：
--
通讯作者：
Grant KA
中科院分区：
文献类型：
--
作者：
Baker EJ;Farro J;Gonzales S;Helms C;Grant KA
目前的酒精使用障碍（AUD）标准不包括酒精摄入量（数量/频率）测量，部分原因是这些测量对人类来说很困难。乙醇自我给药的动物模型对于增进我们对 (AUD) 神经生物学基础的理解至关重要，并且可以通过长时间的准确测量来解决数量/频率测量问题。自愿口服酒精自我管理的非人类灵长类动物 (NHP) 模型已记录了酗酒和饮酒依赖的情况，可用于测试消费措施随时间的稳定性。在这里，对大量恒河猴 (Macaca mulatta) 群体 (n=31) 的大量酒精摄入量 (g/kg/天) 进行了分析。所有动物的每日乙醇摄入量在长期（12 个月）摄入中均匀分布。这种摄入量分布的基础是猴子亚群，它们表现出独特的饮酒模式集群，使我们能够明确定义大量饮酒（VHD）、大量饮酒（HD）、暴饮暴食（BD）和低度饮酒（LD）。这些类别在协议评估的 12 个月内保持稳定，但在较短的时间间隔内进行检查时表现出波动。基于数量/频率建立持续饮酒类别表明，消费变量可用于跟踪与我们对诊断、预防、干预和治疗功效的理解相关的行为、分子或生理化学机制的长期变化。
The current criteria for alcohol use disorders (AUD) do not include consumption (quantity/frequency) measures of alcohol intake, in part due to the difficulty of these measures in humans. Animal models of ethanol self-administration have been fundamental in advancing our understanding of the neurobiological basis of (AUD) and can address quantity/frequency measures with accurate measurements over prolonged periods of time. The non-human primate (NHP) model of voluntary oral alcohol self-administration has documented both binge drinking and drinking to dependence and can be used to test the stability of consumption measures over time. Here, an extensive set of alcohol intakes (g/kg/day) was analyzed from a large multi-cohort population of Rhesus (Macaca mulatta) monkeys (n=31). Daily ethanol intake was uniformly distributed over chronic (12 months) access for all animals. Underlying this distribution of intakes were subpopulations of monkeys that exhibited distinctive clustering of drinking patterns, allowing us to categorically define very heavy drinking (VHD), heavy drinking (HD), binge drinking (BD), and low drinking (LD). These categories were stable across the 12-month assessed by the protocol, but exhibited fluctuations when examined at shorter intervals. The establishment of persistent drinking categories based on quantity/frequency suggests that consumption variables can be used to track long-term changes in behavioral, molecular or physiochemical mechanisms related to our understanding of diagnosis, prevention, intervention and treatment efficacies.
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影响因子：
3.4
作者：
Matson LM;Grahame NJ
通讯作者：
Grahame NJ
DOI：
10.1097/01.alc.0000113422.04849.fa
发表时间：
2004-02-01
影响因子：
3.2
作者：
Monti, PM;Tidey, J;Pierre, P
通讯作者：
Pierre, P
影响因子：
3.2
作者：
Matson, Liana M.;Kasten, Chelsea R.;Grahame, Nicholas J.
通讯作者：
Grahame, Nicholas J.
影响因子：
4.2
作者：
Saha, Tulshi D.;Stinson, Frederick S.;Grant, Bridget F.
通讯作者：
Grant, Bridget F.
DOI：
10.1111/j.1530-0277.2008.00806.x
发表时间：
2008-12
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Dawson DA;Goldstein RB;Chou SP;Ruan WJ;Grant BF
通讯作者：
Grant BF