Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors.
Regulation of Energy Expenditure and Brown/Beige Thermogenic Activity by Interleukins: New Roles for Old Actors.
复制标题
DOI：
10.3390/ijms19092569
复制
发表时间：
2018-08-29
影响因子：
5.6
通讯作者：
Diéguez C
中科院分区：
文献类型：
--
作者：
García MDC;Pazos P;Lima L;Diéguez C
肥胖率和代谢相关疾病的负担在全球范围内不断上升，人类脂肪组织（AT）中的能量燃烧棕色和可诱导的米色脂肪细胞由于其对抗营养过载和超重的有害代谢作用的治疗潜力而引起了相当大的关注。最近的研究强调了居民和招募AT的免疫细胞群及其信号传导介质，细胞因子，作为棕色和米色AT的产热活性的调节剂的相关性。在这篇综述中，我们首先提供了一个概述的AT器官的发育，细胞和功能的异质性，以及报告的分子开关的产热机制。我们还讨论了各种白细胞介素信号通路的能量和代谢的稳态及其在棕色和米色脂肪细胞的生物发生和功能的作用的关键贡献。除了当地的行动，也提请注意他们的影响，在中枢神经系统（CNS）网络管理的能量消耗。
Obesity rates and the burden of metabolic associated diseases are escalating worldwide Energy burning brown and inducible beige adipocytes in human adipose tissues (ATs) have attracted considerable attention due to their therapeutic potential to counteract the deleterious metabolic effects of nutritional overload and overweight. Recent research has highlighted the relevance of resident and recruited ATs immune cell populations and their signalling mediators, cytokines, as modulators of the thermogenic activity of brown and beige ATs. In this review, we first provide an overview of the developmental, cellular and functional heterogeneity of the AT organ, as well as reported molecular switches of its heat-producing machinery. We also discuss the key contribution of various interleukins signalling pathways to energy and metabolic homeostasis and their roles in the biogenesis and function of brown and beige adipocytes. Besides local actions, attention is also drawn to their influence in the central nervous system (CNS) networks governing energy expenditure.
登录
查看更多内容
影响因子：
8.1
作者：
Bolus WR;Peterson KR;Hubler MJ;Kennedy AJ;Gruen ML;Hasty AH
通讯作者：
Hasty AH
影响因子：
5.8
作者：
Bastard, JP;Jardel, C;Hainque, B
通讯作者：
Hainque, B
影响因子：
3.7
作者：
Barra NG;Palanivel R;Denou E;Chew MV;Gillgrass A;Walker TD;Kong J;Richards CD;Jordana M;Collins SM;Trigatti BL;Holloway AC;Raha S;Steinberg GR;Ashkar AA
通讯作者：
Ashkar AA
影响因子：
6.9
作者：
Almendro, Vanessa;Fuster, Gemma;Lopez-Soriano, Francisco J.
通讯作者：
Lopez-Soriano, Francisco J.
影响因子：
64.8
作者：
Camell CD;Sander J;Spadaro O;Lee A;Nguyen KY;Wing A;Goldberg EL;Youm YH;Brown CW;Elsworth J;Rodeheffer MS;Schultze JL;Dixit VD
通讯作者：
Dixit VD