Regulated RNA stability in the Gram positives.

Regulated RNA stability in the Gram positives.
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DOI:
10.1016/j.mib.2011.01.010
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发表时间:
2011-04
影响因子:
5.4
通讯作者:
Bechhofer, David H.
Bechhofer, David H.
中科院分区:
生物学2区
文献类型:
--
作者:
Condon, Ciaran;Bechhofer, David H.

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Regulation of bacterial gene expression at the post-transcriptional level has emerged as a major control mechanism, although not yet as well recognized as the mechanisms of control at the transcriptional level. In this article, we focus on regulated RNA decay in the control of gene expression in Gram-positive organisms, with a focus on Bacillus subtilis. Discovery of new ribonuclease activities in B. subtilis and other Gram-positive species, especially the dual-functioning RNase J1, which specifies both an endonuclease activity and the long-sought bacterial 5’-to-3’ exoribonuclease activity, has led to the recognition of intriguing mechanisms of gene regulation at the level of RNA decay.
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