Vaginal and Extra-Vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women Who Have Sex With Men.

Vaginal and Extra-Vaginal Bacterial Colonization and Risk for Incident Bacterial Vaginosis in a Population of Women Who Have Sex With Men.
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DOI:
10.1093/infdis/jiaa233
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发表时间:
2022-04-01
期刊:
The Journal of infectious diseases
影响因子:
--
通讯作者:
Marrazzo JM
Marrazzo JM
中科院分区:
其他
文献类型:
--
作者:
Fredricks DN;Plantinga A;Srinivasan S;Oot A;Wiser A;Fiedler TL;Proll S;Wu MC;Marrazzo JM

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细菌性阴道病(BV)是引起阴道分泌物的常见原因,与阴道感染BV相关细菌(BVAB)有关。我们使用定量聚合酶链式反应分析来确定BV前口腔、肛门、阴道或阴唇中BVAB的存在或浓度是否可以预测72名与男性发生BV的女性发生BV的风险。在发生BV的受试者中,基础阴道和阴道外定植的加德纳氏菌属、巨型杆菌属、Sneathia属、BVAB-2、Dialister sp2和其他BVAB类更常见。BVAB以前的定植对BV来说是一个一贯的风险。在无细菌性阴道病的女性中,口腔、肛门、阴唇和阴道中检测到的细菌性阴道病相关细菌的存在和浓度可以预测那些随后发展为BV的女性。
Bacterial vaginosis (BV) is a common cause of vaginal discharge and associated with vaginal acquisition of BV-associated bacteria (BVAB). We used quantitative polymerase chain reaction assays to determine whether presence or concentrations of BVAB in the mouth, anus, vagina, or labia before BV predict risk of incident BV in 72 women who have sex with men. Baseline vaginal and extra-vaginal colonization with Gardnerella spp, Megasphaera spp, Sneathia spp, BVAB-2, Dialister sp type 2, and other BVAB was more common among subjects with incident BV. Prior colonization with BVAB is a consistent risk for BV. The presence and concentrations of bacterial vaginosis-associated bacteria detected in the mouth, anus, labia, and vagina of women without bacterial vaginosis predict those women who subsequently develop BV.
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