Human Xenografts, Human Skin and Skin Reconstructs for Studies in Melanoma Development and Progression
Human Xenografts, Human Skin and Skin Reconstructs for Studies in Melanoma Development and Progression
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用于黑色素瘤发生和进展研究的人类异种移植、人类皮肤和皮肤重建
DOI：
10.1023/a:1006333627271
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发表时间：
2004
影响因子：
9.2
通讯作者：
M. Herlyn
中科院分区：
文献类型：
--
作者：
K. Satyamoorthy;F. Meier;M. Hsu;C. Berking;M. Herlyn
黑色素瘤从一系列结构和表型上不同的阶段发展而来，并逐渐变得具有侵略性。在了解人类黑色素瘤的生物学、病理学和免疫学方面已经取得了相当大的进展。遗传学和细胞遗传学研究揭示了广泛的染色体异常和广泛的突变谱。导致黑色素瘤进展的确切生物学和分子决定因素尚不清楚。这部分是由于缺乏模拟人类黑色素瘤的实验模型。黑色素瘤的实验模型不仅应该确定恶性肿瘤的原因和起源，而且应该代表有序的进展步骤，最终转移到远处器官。目前，有几种小鼠和其他脊椎动物黑色素瘤模型正在研究中；其中一些有望揭示黑色素瘤形成的机制。然而，他们中的许多人都缺乏人类皮肤结构的背景，因此，是基本的兴趣。缺乏适当的模型阻碍了了解起源、病因、进展和最终对人类的治疗益处的努力。人-鼠嵌合模型的开发具有吸引力，因为它可以模拟人类疾病。此外，体外构建的人造皮肤有望成为一种多功能和高效的模型，不仅可以研究黑色素瘤的起源和机制，还可以研究其进展。本文将重点介绍黑色素瘤建立肿瘤模型的最新进展及其作为肿瘤进展的分子决定因素与人类黑色素瘤的相关性。
Melanoma develops from a series of architectural and phenotypically distinct stages and becomes progressively aggressive. Considerable progress has been made in understanding the biological, pathological, and immunological aspects of human melanoma. Genetic and cytogenetic studies have revealed broad chromosomal abnormalities and wide mutational spectra. Precise biological and molecular determinants responsible for melanoma progression are not yet known. This is in part due to lack of experimental models that mimic human melanomas. Experimental models in melanoma should not only identify cause and origin of malignancy, but also should represent the ordered progression steps that culminate in metastasis to distant organs. Currently, there are several mouse and other vertebrate melanoma models under investigation; several of them promise to shed light on mechanisms of melanomagenesis. However, many of them suffer from lack of context to human skin architecture and hence, are of basic interest. The lack of appropriate models impeded the efforts to understand origin, etiology, progression and ultimately therapeutic benefits to humans. Development of human skin–mouse chimeric models has appeal because it mimics human diseases. In addition, human artificial skin constructs in vitro promises to be a versatile and efficient model to study not only origin and mechanisms of melanoma, but also progression. This review will focus on the recent progress in establishing tumor models in melanoma in general and their relevance to human melanoma as molecular determinants of tumor progression.
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DOI：
--
发表时间：
1993-08
期刊：
The American journal of pathology
影响因子：
--
作者：
I. Juhász;S. Albelda;D. Elder;G. Murphy;K. Adachi;D. Herlyn;I. Vályi-Nagy;M. Herlyn
通讯作者：
I. Juhász;S. Albelda;D. Elder;G. Murphy;K. Adachi;D. Herlyn;I. Vályi-Nagy;M. Herlyn
DOI：
10.1073/pnas.94.2.701
发表时间：
1997-01-21
影响因子：
11.1
作者：
Takayama, H;LaRochelle, WJ;Merlino, G
通讯作者：
Merlino, G
黑色素瘤转移的关键决定因素。
DOI：
--
发表时间：
1996
期刊：
The journal of investigative dermatology. Symposium proceedings
影响因子：
--
作者：
Fidler,IJ
通讯作者：
Fidler,IJ
影响因子：
6
作者：
Hsu, MY;Shih, DT;Herlyn, M
通讯作者：
Herlyn, M
使用 RAG-1 小鼠异种移植模型，UVB 诱导人类皮肤上皮肿瘤。
DOI：
10.1111/1523-1747.ep12340661
发表时间：
1997
期刊：
The Journal of investigative dermatology.
影响因子：
--
作者：
Atillasoy,ES;Elenitsas,R;Sauter,ER;Soballe,PW;Herlyn,M
通讯作者：
Herlyn,M