UVB induction of epithelial tumors in human skin using a RAG-1 mouse xenograft model.
UVB induction of epithelial tumors in human skin using a RAG-1 mouse xenograft model.
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使用 RAG-1 小鼠异种移植模型，UVB 诱导人类皮肤上皮肿瘤。
DOI：
10.1111/1523-1747.ep12340661
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Herlyn,M
中科院分区：
文献类型：
--
作者：
Atillasoy,ES;Elenitsas,R;Sauter,ER;Soballe,PW;Herlyn,M
为了检测慢性紫外线对人表皮细胞的影响，我们将白色人皮肤移植到重组酶激活基因-1基因敲除小鼠身上。我们以前发现，当每周给药三次时，人皮肤移植物对紫外线8辐射(290-320 nm)的最大耐受浓度为500J/m2。158只移植的小鼠被随机分成四组，观察时间的中位数为10个月：(I)不处理：(Ii)化学致癌物二甲基苯并茂；(Iii)中波紫外线B，每周三次；以及(Iv)二甲基苯并中波紫外线B的组合。大约一半经中波紫外线B处理的皮肤样本出现浅表糜烂和表皮囊。在治疗开始后的4到8个月内，移植物含有多达7个毫米样的病变，而较大的表皮囊肿的数量很少超过两个。无论是色素沉着还是晒黑，皮肤上都会长出朱砂和囊泡。9%的移植物发生光化性角化病，9%的移植物发生光化性角化病，19%的移植物接受二甲基苯并菲和紫外线B的联合治疗，10%的移植物发生浸润性鳞状细胞癌，病变仅限于不晒黑的移植物。这些发现表明：(1)紫外线诱导的皮肤损伤可以在实验上加速发展；(2)在慢性紫外线B研究中，异种移植重组酶激活基因-1缺陷小鼠优于严重联合免疫缺陷病小鼠；(3)良性囊性肿瘤和鳞癌是由紫外线B引起的。
To examine the effects of chronic ultraviolet light on human epidermal cells, we grafted white human skin onto recombinase activating gene-1 knockout mice. We found previously that the maximal concentration of ultraviolet 8 radiation (290–320 nm) tolerated by human skin xenografts was 500 J per m2when given three times weekly. One hundred and fifty-eight grafted mice were randomized and observed for a median of 10 mo in four groups: (i) no treatment: (ii) one treatment with the chemical carcinogen dimethy-(a)benzanthracene; (iii) ultraviolet B three times weekly; and (iv) a combination of dimethyl-(a)benzanthracene and ultraviolet B. Approximately half of the skin specimens treated with ultraviolet B developed superficial milia and epidermal cysts. Grafts contained up to seven milia lesions between 4 and 8 mo after initiation of treatment, whereas the number of larger epidermal cysts was rarely more than two. Milia and cysts developed in the skin regardless of pigmentation or tanning. Actinic keratoses arose in 9% of grafts treated with ultraviolet B alone and in 19% of grafts treated with the combination of dimethyl-(a)benzanthracene and ultraviolet B. Invasive squamous cell carcinomas developed in 10% of grafts after combined dimethyl-(a)benzanthracene and ultraviolet B treatment and lesions were restricted to skin grafts that did not tan. These findings demonstrate that (i) development of ultraviolet-induced lesions can be experimentally accelerated in human skin, (ii) xenografted recombinase activating gene-1 deficient mice are superior to severe combined immunodeficiency disease mice for chronic ultraviolet B studies, and (iii) benign cystic tumors and squamous cell carcinomas are caused by ultraviolet B.
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紫外线照射诱导的白细胞介素-1 和碱性成纤维细胞生长因子的合成和释放介导了紫外线反应的一部分。
DOI：
10.1016/s0021-9258(18)53311-1
发表时间：
1993
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Marcus Kramer;C. Sachsenmaier;Peter Herrlich;Hans J. RahmsdorfS
通讯作者：
Hans J. RahmsdorfS
DOI：
--
发表时间：
1993-08
期刊：
The American journal of pathology
影响因子：
--
作者：
I. Juhász;S. Albelda;D. Elder;G. Murphy;K. Adachi;D. Herlyn;I. Vályi-Nagy;M. Herlyn
通讯作者：
I. Juhász;S. Albelda;D. Elder;G. Murphy;K. Adachi;D. Herlyn;I. Vályi-Nagy;M. Herlyn
影响因子：
6.5
作者：
PEARSE, AD;GASKELL, SA;MARKS, R
通讯作者：
MARKS, R
DOI：
10.1073/pnas.90.9.4216
发表时间：
1993-05-01
影响因子：
11.1
作者：
ZIEGLER, A;LEFFELL, DJ;BRASH, DE
通讯作者：
BRASH, DE
转录因子 Sp1 与苯并[a]芘二醇环氧化物修饰的 DNA 中非靶位点的结合。
影响因子：
4.7
作者：
MacLeod,MC;Powell,KL;Tran,N
通讯作者：
Tran,N