Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside.
Image-based micro-finite-element modeling for improved distal radius strength diagnosis: moving from bench to bedside.
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基于图像的微有限元建模，用于改进远端桡骨强度诊断：从工作台转移到床边。
DOI：
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发表时间：
2004
影响因子：
2.5
通讯作者：
Peter Rüegsegger
中科院分区：
文献类型：
--
作者：
W. Pistoia;B. Rietbergen;E. Lochmüller;C. Lill;Felix Eckstein;Peter Rüegsegger
尽管骨质疏松症的特点是量（质量）和质（结构）变化，但标准临床技术（双能 X 射线吸收测定法，DXA）仅测量前者。基于高分辨率图像的三维微观有限元 (micro-FE) 模型也可以解释结构方面的问题，最近的研究表明，通过微观 FE 分析可以改进远端半径强度的预测。然而，该技术的临床应用因其高成像和计算要求而受到限制。本研究的目的是调查当仅使用一小部分半径进行微有限元建模时，是否也可以获得改进的骨强度预测。使用三维外围定量计算机断层扫描 (pQCT) 设备以 165 微米分辨率拍摄 54 具尸体手臂（平均年龄：82 +/- 9 SD）的远端桡骨干骺端 1 厘米区域的图像，形成了用于预测骨衰竭负荷的微型有限元模型的基础。成像后，通过实验将样本压缩至无法产生科尔斯型骨折。微观有限元分析预测的失效载荷与实验测量的载荷非常吻合（R2 = 0.66，p < 0.001）。观察到与骨量（R2 = 0.48，p < 0.001）和微观结构参数（R2 = 0.47，p < 0.001）的相关性较低。因此，即使仅对小区域进行建模，微观有限元分析也可以提供改进的半径强度预测。
Although osteoporosis is characterized by quantitative (mass) and qualitative (structural) changes, standard clinical techniques (dual-energy X-ray absorptiometry, DXA) only measure the former. Three-dimensional micro-finite-element (micro-FE) models based on high-resolution images can account for structural aspects as well, and it has recently been shown that an improved prediction of distal radius strength is possible with micro-FE analysis. A clinical application of this technique, however, is limited by its high imaging and computational demands. The objective of this study is to investigate if an improved prediction of bone strength can be obtained as well when only a small part of the radius is used for micro-FE modeling. Images of a 1-cm region of the metaphysis of the distal radius of 54 cadaver arms (mean age: 82 +/- 9 SD) made with a three-dimensional peripheral quantitative computed tomography (pQCT) device at 165- micro m resolution formed the basis for micro-FE models that were used to predict the bone failure load. Following imaging, specimens were experimentally compressed to failure to produce a Colles'-type fracture. Failure loads predicted from micro-FE analyses agreed well with those measured experimentally (R2 = 0.66, p < 0.001). Lower correlations were observed with bone mass (R2 = 0.48, p < 0.001) and microstructural parameters (R2 = 0.47, p < 0.001). Hence, even when only a small region is modeled, micro-FE analysis provides an improved prediction of radius strength.
影响因子：
19.7
作者：
Wehrli, FW;Hwang, SN;Haddad, JG
通讯作者：
Haddad, JG
影响因子：
5
作者：
MELTON, LJ;KAN, SH;RIGGS, BL
通讯作者：
RIGGS, BL