Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10.
Exemestane Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells and Promoting the Secretion of Interleukin 10.
复制标题
依西美坦通过抑制肝星状细胞活化并促进白介素 10 分泌减轻大鼠肝纤维化
DOI：
10.1155/2017/3072745
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发表时间：
2017
影响因子：
4.1
通讯作者：
Zhang ZG
中科院分区：
文献类型：
--
作者：
Wang YH;Li RK;Fu Y;Li J;Yang XM;Zhang YL;Zhu L;Yang Q;Gu JR;Xing X;Zhang ZG
依西美坦（EXE）是一种不可逆的甾体芳香化酶抑制剂，主要用于绝经后妇女乳腺癌的辅助内分泌治疗。除了抑制芳香化酶活性外，EXE还具有多种生物学功能，如抗增殖、抗炎和抗氧化活性，这些都参与肝纤维化。因此，我们研究了EXE在肝纤维化过程中的作用。采用四氯化碳（CCl_4）和胆管结扎（BDL）诱导的大鼠肝纤维化模型，观察EXE对肝损伤和肝纤维化的影响。体外观察EXE对原代大鼠肝星状细胞（HSC）活化和增殖的影响。结果表明，EXE通过减少胶原沉积和α-SMA表达减轻肝纤维化，抑制原代大鼠HSC的活化和增殖。此外，EXE在体内和HSC-T6培养基中促进抗纤维化和抗炎细胞因子IL-10的分泌。总之，我们的研究结果揭示了一个新的功能，EXE对肝纤维化和促进其潜在的应用在肝纤维化相关疾病。
Exemestane (EXE) is an irreversible steroidal aromatase inhibitor mainly used as an adjuvant endocrine therapy for postmenopausal women suffering from breast cancer. Besides inhibiting aromatase activity, EXE has multiple biological functions, such as antiproliferation, anti-inflammatory, and antioxidant activities which are all involved in hepatic fibrosis. Therefore, we investigated the role of EXE during the progress of hepatic fibrosis. The effect of EXE on liver injury and fibrosis were assessed in two hepatic fibrosis rat models, which were induced by either carbon tetrachloride (CCl4) or bile duct ligation (BDL). The influence of EXE treatment on activation and proliferation of primary rat hepatic stellate cells (HSCs) was observed in vitro. The results showed that EXE attenuated the liver fibrosis by decreasing the collagen deposition and α-SMA expression in vivo and inhibited the activation and proliferation of primary rat HSCs in vitro. Additionally, EXE promoted the secretion of antifibrotic and anti-inflammatory cytokine IL-10 in vivo and in HSC-T6 culture media. In conclusion, our findings reveal a new function of EXE on hepatic fibrosis and prompted its latent application in liver fibrotic-related disease.
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影响因子：
13.5
作者：
Suh, Yang-Gun;Kim, Ja Kyung;Byun, Jin-Seok;Yi, Hyon-Seung;Lee, Young-Sun;Eun, Hyuk Soo;Kim, So Yeon;Han, Kwang-Hyub;Lee, Kwan Sik;Duester, Gregg;Friedman, Scott L.;Jeong, Won-Il
通讯作者：
Jeong, Won-Il
DOI：
10.1016/0960-0760(92)90198-r
发表时间：
1992-09-01
影响因子：
4.1
作者：
DISALLE, E;ORNATI, G;COOMBES, RC
通讯作者：
COOMBES, RC
影响因子：
4.1
作者：
Yi, Hyon-Seung;Jeong, Won-Il
通讯作者：
Jeong, Won-Il
影响因子：
3.9
作者：
Altinok, A. Y.;Yildirim, S.;Bese, N. S.
通讯作者：
Bese, N. S.
影响因子：
37.3
作者：
Koutras A;Giannopoulou E;Kritikou I;Antonacopoulou A;Evans TR;Papavassiliou AG;Kalofonos H
通讯作者：
Kalofonos H