The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein.
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein.
复制标题
DOI：
10.1093/ve/veab069
复制
发表时间：
2021
期刊：
影响因子：
5.3
通讯作者：
Wallau GL
中科院分区：
文献类型：
--
作者：
Resende PC;Naveca FG;Lins RD;Dezordi FZ;Ferraz MVF;Moreira EG;Coêlho DF;Motta FC;Paixão ACD;Appolinario L;Lopes RS;Mendonça ACDF;da Rocha ASB;Nascimento V;Souza V;Silva G;Nascimento F;Neto LGL;da Silva FV;Riediger I;Debur MDC;Leite AB;Mattos T;da Costa CF;Pereira FM;Dos Santos CA;Rovaris DB;Fernandes SB;Abbud A;Sacchi C;Khouri R;Bernardes AFL;Delatorre E;Gräf T;Siqueira MM;Bello G;Wallau GL
严重急性呼吸道综合征冠状病毒2型（SARS-CoV-2）刺突（S）糖蛋白的受体结合结构域（RBD）和氨基（N）末端结构域（NTD）的突变可改变其抗原性并促进免疫逃逸。我们发现，在巴西传播的SARS-CoV-2谱系在RBD中具有独立的关注突变，在S蛋白的NTD中获得会聚缺失和插入，这改变了NTD抗原超位点和该区域的其他预测表位。重要的是，我们检测到携带NTD indel的不同P.1谱系的社区传播，NTD indel为1469 -70（这可能影响几种SARS-CoV-2诊断方案），1414和ins 214 ANRN，以及来自B.1.1.33谱系的新VOI N.10携带三种NTD缺失（14144，14211和14256 -258）。这些研究结果支持SARS-CoV-2在巴西的持续广泛传播产生了新的病毒谱系，这些病毒谱系可能比关注的亲本变体对抗体中和更具抗性。
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels ∆69-70 (which can impact several SARS-CoV-2 diagnostic protocols), ∆144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (∆141–144, ∆211, and ∆256–258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.
登录
查看更多内容
DOI：
10.1093/bioinformatics/btx346
发表时间：
2017-10-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Gel B;Serra E
通讯作者：
Serra E
DOI：
10.1126/science.abi6226
发表时间：
2021-08-06
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gobeil SM;Janowska K;McDowell S;Mansouri K;Parks R;Stalls V;Kopp MF;Manne K;Li D;Wiehe K;Saunders KO;Edwards RJ;Korber B;Haynes BF;Henderson R;Acharya P
通讯作者：
Acharya P
影响因子：
64.8
作者：
Kemp SA;Collier DA;Datir RP;Ferreira IATM;Gayed S;Jahun A;Hosmillo M;Rees-Spear C;Mlcochova P;Lumb IU;Roberts DJ;Chandra A;Temperton N;CITIID-NIHR BioResource COVID-19 Collaboration;COVID-19 Genomics UK (COG-UK) Consortium;Sharrocks K;Blane E;Modis Y;Leigh KE;Briggs JAG;van Gils MJ;Smith KGC;Bradley JR;Smith C;Doffinger R;Ceron-Gutierrez L;Barcenas-Morales G;Pollock DD;Goldstein RA;Smielewska A;Skittrall JP;Gouliouris T;Goodfellow IG;Gkrania-Klotsas E;Illingworth CJR;McCoy LE;Gupta RK
通讯作者：
Gupta RK
影响因子：
48
作者：
Kalyaanamoorthy S;Minh BQ;Wong TKF;von Haeseler A;Jermiin LS
通讯作者：
Jermiin LS
影响因子：
56.9
作者：
Baum, Alina;Fulton, Benjamin O.;Kyratsous, Christos A.
通讯作者：
Kyratsous, Christos A.