Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms.
Why is elevation of serum cholesterol associated with exposure to perfluoroalkyl substances (PFAS) in humans? A workshop report on potential mechanisms.
复制标题
为什么血清胆固醇升高与人体接触全氟烷基物质（PFAS）有关？关于潜在机制的研讨会报告。
DOI：
10.1016/j.tox.2021.152845
复制
发表时间：
2021-07
期刊：
影响因子：
4.5
通讯作者：
Longnecker, Matthew P.
中科院分区：
文献类型：
--
作者：
Andersen, Melvin E.;Hagenbuch, Bruno;Apte, Udayan;Corton, J. Christopher;Fletcher, Tony;Lau, Christopher;Roth, William L.;Staels, Bart;Vega, Gloria L.;Clewell, Harvey J.;Longnecker, Matthew P.
人体血清胆固醇浓度与全氟辛酸（PFOA）和全氟辛烷磺酸（PFOS）的暴露量呈正相关。在广泛的 PFOA 和 PFOS 暴露范围内，胆固醇的相关变化很小。动物研究通常没有表明可以解释人类这种关联的机制。这种关系的因果关系程度是一个悬而未决的问题。尽管如此，这种关联特别重要，因为血清胆固醇升高已被认为是至少在最近的一项风险评估中得出出发点的终点。为了深入了解该关联的潜在机制（因果和非因果），专家研讨会于2019年10月31日和11月1日举行，讨论相关数据并提出新的研究。在本报告中，我们总结了相关背景数据、与会者的讨论以及他们对进一步研究的建议。
Serum concentrations of cholesterol are positively correlated with exposure to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) in humans. The associated change in cholesterol is small across a broad range of exposure to PFOA and PFOS. Animal studies generally have not indicated a mechanism that would account for the association in humans. The extent to which the relationship is causal is an open question. Nonetheless, the association is of particular importance because increased serum cholesterol has been considered as an endpoint to derive a point of departure in at least one recent risk assessment. To gain insight into potential mechanisms for the association, both causal and non-causal, an expert workshop was held Oct 31 and Nov 1, 2019 to discuss relevant data and propose new studies. In this report, we summarize the relevant background data, the discussion among the attendees, and their recommendations for further research.
登录
查看更多内容
影响因子：
3.8
作者：
Beggs KM;McGreal SR;McCarthy A;Gunewardena S;Lampe JN;Lau C;Apte U
通讯作者：
Apte U
影响因子：
0.8
作者：
Athyros, Vasilios G;Kakafika, Anna I;Papageorgiou, Athanasios A;Pagourelias, Efstathios D;Savvatianos, Savvas D;Elisaf, Moses;Karagiannis, Asterios;Tziomalos, Konstantinos;Mikhailidis, Dimitri P
通讯作者：
Mikhailidis, Dimitri P
影响因子：
10.4
作者：
Calafat, Antonia M;Wong, Lee-Yang;Kuklenyik, Zsuzsanna;Reidy, John A;Needham, Larry L
通讯作者：
Needham, Larry L
影响因子：
3.5
作者：
Butenhoff, John L.;Pieterman, Elsbeth;Princen, Hans M. G.
通讯作者：
Princen, Hans M. G.
影响因子：
4.5
作者：
Bogdanska, Jasna;Borg, Daniel;Nobel, Stefan
通讯作者：
Nobel, Stefan