Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis.
Total cholesterol, arterial stiffness, and systolic blood pressure: a mediation analysis.
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总胆固醇、动脉僵硬度和收缩压：中介分析。
DOI：
10.1038/s41598-020-79368-x
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发表时间：
2021-01-14
影响因子：
4.6
通讯作者：
Wu S
中科院分区：
文献类型：
--
作者：
Chen H;Chen Y;Wu W;Cai Z;Chen Z;Yan X;Wu S
本研究以开滦45,092名受试者(平均年龄54.04 ± 13.09岁)为研究对象，探讨总胆固醇(TC)、臂踝脉搏波速度(BaPWV)和收缩压(SBP)之间的关系，并量化它们各自的影响。用多元线性回归模型分析TC、SBP和BaPWV之间的相关性。进行中介分析，以确定TC对SBP的影响是否可以用动脉僵硬来解释。多元线性回归分析显示，TC和BaPWV每增加1个标准差，SBP分别增加0.33 mm Hg和0.044 mm Hg；TC每增加1个标准差，BaPWV增加5.34 cm/S。中介分析显示，TC诱导的SBP升高在超过半数的队列中由动脉僵硬介导(间接效应，0.73；中介百分比，54.5%)。此外，在不到一半的男性中，TC诱导的SBP升高是由动脉僵硬介导的(间接影响，0.70；中介百分比，47.9%)；然而，在女性中，结果没有统计学意义。结论：TC、BaPWV与SBP呈正相关，TC与BaPWV呈正相关。导致TC的SBP增加几乎有一半是由动脉僵硬引起的。
On the basis of 45,092 participants (mean age of 54.04 ± 13.09 years) from the Kailuan study, this study was performed to explore the relationships among total cholesterol (TC), brachial-ankle pulse wave velocity (BaPWV), and systolic blood pressure (SBP) and quantify their separate effects. The correlations among TC, SBP, and BaPWV were analyzed using multivariate linear regression models. Mediation analysis was performed to determine whether the effect of TC on SBP can be explained by arterial stiffness. Multivariate linear regression analysis showed that for every one standard deviation increase in TC and BaPWV, SBP increased by 0.33 mmHg and 0.044 mmHg, respectively; for every one standard deviation increase in TC, BaPWV increased by 5.34 cm/s. Mediation analysis showed that the TC-induced SBP elevation was mediated by arterial stiffness in more than half of the whole cohort (indirect effect, 0.73; percent mediated, 54.5%). Furthermore, the TC-induced SBP elevation was mediated by arterial stiffness in less than half of the males (indirect effect, 0.70; percent mediated, 47.9%); however, the results were not statistically significant in females. In conclusion, TC and BaPWV are positively correlated with SBP, whereas TC is positively correlated with BaPWV. Almost half of the increase in SBP contributed to TC is mediated by arterial stiffness.
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影响因子：
7.3
作者：
Barua RS;Sharma M;Dileepan KN
通讯作者：
Dileepan KN
影响因子：
37.8
作者：
BONAA, KH;THELLE, DS
通讯作者：
THELLE, DS
DOI：
10.1161/hypertensionaha.109.147850
发表时间：
2010-04
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Dengo AL;Dennis EA;Orr JS;Marinik EL;Ehrlich E;Davy BM;Davy KP
通讯作者：
Davy KP
DOI：
10.1161/hypertensionaha.114.00921
发表时间：
2014-07
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Mitchell GF
通讯作者：
Mitchell GF
影响因子：
2.9
作者：
Cui, JSS;Sheffield, LJ
通讯作者：
Sheffield, LJ