Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears.
Full-thickness supraspinatus tears are associated with more synovial inflammation and tissue degeneration than partial-thickness tears.
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DOI：
10.1016/j.jse.2011.02.015
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发表时间：
2011-09
影响因子：
3
通讯作者：
Warren, Russell F.
中科院分区：
文献类型：
--
作者：
Shindle, Michael K.;Chen, Christopher C. T.;Robertson, Catherine;DiTullio, Alexandra E.;Paulus, Megan C.;Clinton, Camille M.;Cordasco, Frank A.;Rodeo, Scott A.;Warren, Russell F.
本研究的目的是确定在接受肩关节镜肩袖修复的患者中，冈上肌腱撕裂的大小是否与滑膜炎症和肌腱变性有关。我们假设滑膜炎症的增加与手术时冈上肌腱撕裂的大小相关。取肩关节镜检查患者的滑膜、法氏囊、冈上肌腱撕裂和肩胛下肌腱组织，观察肌腱、法氏囊和滑膜组织中促炎细胞因子、组织重塑和血管生成因子的表达。固定额外的组织以确定组织学变化，包括炎症、血管内生和胶原组织。完全性撕裂组滑膜组织中IL-1β、IL-6、COX-2、MMP9和血管内皮生长因子的表达明显高于部分撕裂组(P<0.05)。在冈上肌腱中，全厚组中，基质金属蛋白酶-1、-9、-13和血管内皮生长因子的表达增加。组织学结果显示，全厚肌腱中这些基因的表达上调与滑膜炎症增强、血管生长增多以及冈上肌腱和肩胛下肌腱的胶原组织丢失相一致。滑膜炎症和组织变性的增加与冈上肌腱撕裂的大小有关。更好地了解滑膜炎症和肌腱退行性变之间的关系有助于设计新的有效的治疗方法来限制肩袖疾病的进展并改善其临床结果。基础科学、分子和细胞生物学研究
The objective of this study was to determine whether the tear size of a supraspinatus tendon correlated with synovial inflammation and tendon degeneration in patients that underwent shoulder arthroscopy for rotator cuff repair. We hypothesized that increased synovial inflammation would correlate with greater tear size of the supraspinatus tendon at the time of surgery. Tissue from the synovium, bursa, torn supraspinatus tendon and subscapularis tendon were obtained from patients during shoulder arthroscopy in order to evaluate the mRNA expression of pro-inflammatory cytokines, tissue remodeling and angiogenesis factors in the tendon, bursa, and synovium. Additional tissue was fixed to determine histological changes including inflammation, vascular ingrowths, and collagen organization. Increased expression of IL-1β, IL-6, COX-2, MMP-9, and VEGF was found in the synovium of patients with full-thickness tears versus partial-thickness tears (p<0.05). In the supraspinatus tendon, increased expression of MMP-1, -9, and -13 and VEGF was found in the full-thickness group. The upregulation of these genes in the full-thickness group was consistent with enhanced synovium inflammation, greater vascular ingrowth and the loss of collagen organization in both supraspinatus and subscapularis tendons as determined by histology. Increased synovium inflammation and tissue degeneration correlates with the tear size of the supraspinatus tendon. A better understanding of the relationship between synovial inflammation and the progression of tendon degeneration can help design novel and effective treatments to limit the advance of rotator cuff diseases and to improve their clinical outcomes. Basic Science, Molecular and Cell Biology Study
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影响因子：
7
作者：
Pearle, A. D.;Scanzello, C. R.;Crow, M. K.
通讯作者：
Crow, M. K.
DOI：
10.2106/00004623-200304000-00016
发表时间：
2003-04-01
影响因子：
5.3
作者：
Harryman, DT;Hettrich, CM;Matsen, FA
通讯作者：
Matsen, FA
影响因子：
2.8
作者：
Choi, HR;Kondo, S;Iwata, H
通讯作者：
Iwata, H
影响因子：
4.8
作者：
Cordasco, FA;Backer, M;Warren, RF
通讯作者：
Warren, RF
影响因子：
4.2
作者：
Maffulli, Nicola;Longo, Umile Giuseppe;Denaro, Vincenzo
通讯作者：
Denaro, Vincenzo