Macrophage Plasticity in Reproduction and Environmental Influences on Their Function.
Macrophage Plasticity in Reproduction and Environmental Influences on Their Function.
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DOI：
10.3389/fimmu.2020.607328
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发表时间：
2020
影响因子：
7.3
通讯作者：
Thornton CA
中科院分区：
文献类型：
--
作者：
Chambers M;Rees A;Cronin JG;Nair M;Jones N;Thornton CA
巨噬细胞是天然免疫系统的重要组成部分，具有广泛的可塑性和异质性。它们在非妊娠的周期子宫中扮演着重要的角色，在整个妊娠过程中，它们对支撑生殖成功的各种过程做出了贡献，包括着床、胎盘和分娩。巨噬细胞也存在于母乳中，对婴儿具有免疫调节作用。对于健康的妊娠，母体免疫系统必须适应，以防止胎儿排斥反应，并在不损害宿主防御的情况下支持半异基因胎儿的发育。这些功能依赖于巨噬细胞的极化，巨噬细胞的极化受局部组织微环境的控制。这种微环境的破坏，可能是由感染性和非感染性的环境因素造成的，可以影响巨噬细胞的表型和功能，并与产科的不利结果有关，如自发流产和早产。确定环境对控制母胎界面巨噬细胞极化的细胞和分子机制的影响，以及这种影响在妊娠并发症中的作用，可以支持减轻不良妊娠结局的方法。
Macrophages are key components of the innate immune system and exhibit extensive plasticity and heterogeneity. They play a significant role in the non-pregnant cycling uterus and throughout gestation they contribute to various processes underpinning reproductive success including implantation, placentation and parturition. Macrophages are also present in breast milk and impart immunomodulatory benefits to the infant. For a healthy pregnancy, the maternal immune system must adapt to prevent fetal rejection and support development of the semi-allogenic fetus without compromising host defense. These functions are dependent on macrophage polarization which is governed by the local tissue microenvironmental milieu. Disruption of this microenvironment, possibly by environmental factors of infectious and non-infectious origin, can affect macrophage phenotype and function and is linked to adverse obstetric outcomes, e.g. spontaneous miscarriage and preterm birth. Determining environmental influences on cellular and molecular mechanisms that control macrophage polarization at the maternal-fetal interface and the role of this in pregnancy complications could support approaches to alleviating adverse pregnancy outcomes.
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影响因子：
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作者：
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通讯作者：
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