The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs.
The comparative RNA web (CRW) site: an online database of comparative sequence and structure information for ribosomal, intron, and other RNAs.
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DOI：
10.1186/1471-2105-3-2
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发表时间：
2002
影响因子：
3
通讯作者：
Gutell RR
中科院分区：
文献类型：
--
作者：
Cannone JJ;Subramanian S;Schnare MN;Collett JR;D'Souza LM;Du Y;Feng B;Lin N;Madabusi LV;Müller KM;Pande N;Shang Z;Yu N;Gutell RR
RNA序列的比较分析是详细和准确预测RNA结构和确定跨越整个系统发育树的生物的系统发育关系的基础。在这些成就的背后是非常大的、组织良好的和经过处理的RNA序列集合。这些数据从组织到数据库管理系统中的序列开始，并进行了比对，以揭示其更高级别的结构，以及跨越系统发育树的生物的保护和变异模式，已经收集和分析。这种类型的信息可以是研究系统发育关系、RNA结构以及这两个领域的融合的基础，并对其产生影响。我们准备了一个大型网站，传播我们的比较序列和结构模型和数据。对于三个核糖体RNA(5S、16S和23S rRNA)、转移RNA(TRNA)和两个催化内含子RNA(组I和组II)来说，可用的四种主要类型的比较信息和系统是：(1)当前比较结构模型；(2)核苷酸频率和保守信息；(3)序列和结构数据；以及(4)数据访问系统。这一在线核糖核酸序列和结构信息是经过广泛的分析、解释、数据收集以及计算机程序和网络开发的结果，可在我们的比较核糖核酸网络(CRW)网站http://www.rna.icmb.utexas.edu.获得今后，将在这些现有类别中增加更多的数据和信息，开发新的类别，并将在CRW网站上研究和展示更多的RNA。
Comparative analysis of RNA sequences is the basis for the detailed and accurate predictions of RNA structure and the determination of phylogenetic relationships for organisms that span the entire phylogenetic tree. Underlying these accomplishments are very large, well-organized, and processed collections of RNA sequences. This data, starting with the sequences organized into a database management system and aligned to reveal their higher-order structure, and patterns of conservation and variation for organisms that span the phylogenetic tree, has been collected and analyzed. This type of information can be fundamental for and have an influence on the study of phylogenetic relationships, RNA structure, and the melding of these two fields. We have prepared a large web site that disseminates our comparative sequence and structure models and data. The four major types of comparative information and systems available for the three ribosomal RNAs (5S, 16S, and 23S rRNA), transfer RNA (tRNA), and two of the catalytic intron RNAs (group I and group II) are: (1) Current Comparative Structure Models; (2) Nucleotide Frequency and Conservation Information; (3) Sequence and Structure Data; and (4) Data Access Systems. This online RNA sequence and structure information, the result of extensive analysis, interpretation, data collection, and computer program and web development, is accessible at our Comparative RNA Web (CRW) Site http://www.rna.icmb.utexas.edu. In the future, more data and information will be added to these existing categories, new categories will be developed, and additional RNAs will be studied and presented at the CRW Site.
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影响因子：
10.7
作者：
Bhattacharya, D;Lutzoni, F;Fernandez, F
通讯作者：
Fernandez, F
影响因子：
14.9
作者：
GUTELL, RR;GRAY, MW;SCHNARE, MN
通讯作者：
SCHNARE, MN
影响因子：
5.6
作者：
Elgavish, T;Cannone, JJ;Gutell, RR
通讯作者：
Gutell, RR
影响因子：
2.5
作者：
Bhattacharya, D;Cannone, JJ;Gutell, RR
通讯作者：
Gutell, RR
影响因子：
14.9
作者：
BRANLANT, C;KROL, A;KOSSEL, H
通讯作者：
KOSSEL, H