Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
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DOI：
10.1038/ncomms8000
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发表时间：
2015-05-12
影响因子：
16.6
通讯作者：
Todd JA
中科院分区：
文献类型：
--
作者：
Dopico XC;Evangelou M;Ferreira RC;Guo H;Pekalski ML;Smyth DJ;Cooper N;Burren OS;Fulford AJ;Hennig BJ;Prentice AM;Ziegler AG;Bonifacio E;Wallace C;Todd JA
尽管许多疾病和生理过程表现出年度周期性，但季节性变化很少被认为是对人体组织功能或健康有贡献的组成部分。在这里，我们发现白细胞和脂肪组织中有4000多种蛋白质编码mrna具有季节性表达谱，在欧洲和大洋洲之间观察到相反的模式。我们还发现血液的细胞成分随季节而变化，这些变化在英国和冈比亚之间有所不同，可以解释基因表达的周期性。在组织功能方面，在欧洲冬季，免疫系统具有深刻的促炎转录组谱，可溶性IL-6受体和c反应蛋白水平升高，心血管、精神和自身免疫性疾病的风险生物标志物在冬季发病率最高。因此，作为人类生理和疾病的各个方面的贡献者，周期节律需要进一步的探索。传染病和慢性病表现出季节性模式，但很少认为生理上的季节性变化会影响人类健康。在这里，作者展示了所有主要血细胞以及不同组织中基因和蛋白质表达的季节性变化，这提示了季节性疾病易感性和生理学的机制。
Seasonal variations are rarely considered a contributing component to human tissue function or health, although many diseases and physiological process display annual periodicities. Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania. We also find the cellular composition of blood to vary by season, and these changes, which differ between the United Kingdom and The Gambia, could explain the gene expression periodicity. With regards to tissue function, the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter. Circannual rhythms thus require further exploration as contributors to various aspects of human physiology and disease. Infectious and chronic diseases display seasonal patterns, yet seasonal changes in physiology are rarely thought to affect human health. Here the authors show seasonal variation in all major blood cells and in gene and protein expression in diverse tissues, suggesting a mechanism for seasonal disease proneness and physiology.
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影响因子：
56.9
作者：
Harmer, SL;Hogenesch, LB;Kay, SA
通讯作者：
Kay, SA
影响因子：
8.1
作者：
Dyar KA;Ciciliot S;Wright LE;Biensø RS;Tagliazucchi GM;Patel VR;Forcato M;Paz MI;Gudiksen A;Solagna F;Albiero M;Moretti I;Eckel-Mahan KL;Baldi P;Sassone-Corsi P;Rizzuto R;Bicciato S;Pilegaard H;Blaauw B;Schiaffino S
通讯作者：
Schiaffino S
影响因子：
3.5
作者：
Ebling, Francis J. P.
通讯作者：
Ebling, Francis J. P.
影响因子：
64.5
作者：
Brandes M;Klauschen F;Kuchen S;Germain RN
通讯作者：
Germain RN
影响因子：
4.5
作者：
Ferreira RC;Freitag DF;Cutler AJ;Howson JM;Rainbow DB;Smyth DJ;Kaptoge S;Clarke P;Boreham C;Coulson RM;Pekalski ML;Chen WM;Onengut-Gumuscu S;Rich SS;Butterworth AS;Malarstig A;Danesh J;Todd JA
通讯作者：
Todd JA