MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe.
MRI assessment of cerebral oxygen extraction fraction in the medial temporal lobe.
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DOI：
10.1016/j.neuroimage.2022.119829
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发表时间：
2023-02-01
期刊：
影响因子：
5.7
通讯作者：
Lu, Hanzhang
中科院分区：
文献类型：
--
作者：
Jiang, Dengrong;Liu, Peiying;Lin, Zixuan;Hazel, Kaisha;Pottanat, George;Lucke, Emma;Moghekar, Abhay;Pillai, Jay J.;Lu, Hanzhang
关键词：
内侧颞叶（MTL）是与许多脑部疾病（例如阿尔茨海默病）有关的关键区域。作为一种功能性生物标志物，MTL 的氧提取分数（OEF）可能比 MTL 的结构萎缩更敏感，尤其是在疾病的早期阶段。然而，缺乏测量人类 MTL-OEF 的非侵入性技术。这项工作的目标是开发一种 MRI 技术，在临床实践中无需使用造影剂即可评估 MTL-OEF。所提出的方法测量罗森塔尔基底静脉 (BV) 中的静脉氧合 (Yv)，这是 MTL 的主要引流静脉。然后可以将 MTL-OEF 估计为氧合动静脉差异。我们开发了一种 MRI 序列，称为动脉抑制加速 T2 松弛相衬 (AS-aTRUPC)，用于量化 BV 的血液 T2，然后通过完善的校准模型将其转换为 Yv。 MTL-OEF 的计算公式为 (Ya − Yv)/Ya × 100%，其中 Ya 是动脉氧合。在 16 名健康成年人中评估了 AS-aTRUPC 量化 MTL-OEF 的可行性。 AS-aTRUPC 在检测 OEF 变化方面的敏感性通过咖啡因摄入（200 毫克）挑战进行评估。为了进行比较，还获得了 T2-自旋标记下松弛 (TRUST) MRI，这是一种广泛使用的全球 OEF 技术。通过纳入另外七名健康老年受试者来检查 MTL-OEF 对年龄的依赖性。结果显示，在健康成年人中，左右半球的MTL-OEF是相关的（P = 0.005）。 MTL-OEF 测量值为 23.9 ± 3.6%（平均值 ± 标准差），显着低于 (P < 0.0001) 上矢状窦 (SSS) 测量的 OEF 33.3 ± 2.9%。摄入咖啡因后，MTL-OEF 的绝对百分比增加了 9.1 ± 4.0%。此外，使用 AS-aTRUPC 测量的 SSS 中的 OEF 显示与 TRUST OEF 具有很强的相关性（组内相关系数 = 0.94，95% 置信区间 [0.91, 0.96]），没有显着偏差 (P = 0.12)。研究发现，MTL-OEF 随着年龄的增长而增加（MTL-OEF = 20.997 + 0.100 × 年龄；P = 0.02）。总之，AS-aTRUPC MRI 提供了 MTL-OEF 的非侵入性评估，并可能促进 MTL-OEF 作为疾病生物标志物的未来临床应用。
The medial temporal lobe (MTL) is a key area implicated in many brain diseases, such as Alzheimer’s disease. As a functional biomarker, the oxygen extraction fraction (OEF) of MTL may be more sensitive than structural atrophy of MTL, especially at the early stages of diseases. However, there is a lack of non-invasive techniques to measure MTL-OEF in humans. The goal of this work is to develop an MRI technique to assess MTL-OEF in a clinically practical time without using contrast agents. The proposed method measures venous oxygenation (Yv) in the basal veins of Rosenthal (BVs), which are the major draining veins of the MTL. MTL-OEF can then be estimated as the arterio-venous difference in oxygenation. We developed an MRI sequence, dubbed arterial-suppressed accelerated T2-relaxation-under-phase-contrast (AS-aTRUPC), to quantify the blood T2 of the BVs, which was then converted to Yv through a well-established calibration model. MTL-OEF was calculated as (Ya − Yv)/Ya × 100%, where Ya was the arterial oxygenation. The feasibility of AS-aTRUPC to quantify MTL-OEF was evaluated in 16 healthy adults. The sensitivity of AS-aTRUPC in detecting OEF changes was assessed by a caffeine ingestion (200 mg) challenge. For comparison, T2-relaxation-under-spin-tagging (TRUST) MRI, which is a widely used global OEF technique, was also acquired. The dependence of MTL-OEF on age was examined by including another seven healthy elderly subjects. The results showed that in healthy adults, MTL-OEF of the left and right hemispheres were correlated (P = 0.005). MTL-OEF was measured to be 23.9 ± 3.6% (mean ± standard deviation) and was significantly lower (P < 0.0001) than the OEF of 33.3 ± 2.9% measured in superior sagittal sinus (SSS). After caffeine ingestion, there was an absolute percentage increase of 9.1 ± 4.0% in MTL-OEF. Additionally, OEF in SSS measured with AS-aTRUPC showed a strong correlation with TRUST OEF (intra-class correlation coefficient = 0.94 with 95% confidence interval [0.91, 0.96]), with no significant bias (P = 0.12). MTL-OEF was found to increase with age (MTL-OEF = 20.997 + 0.100 × age; P = 0.02). In conclusion, AS-aTRUPC MRI provides non-invasive assessments of MTL-OEF and may facilitate future clinical applications of MTL-OEF as a disease biomarker.
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