Bats and zoonotic viruses: can we confidently link bats with emerging deadly viruses?
Bats and zoonotic viruses: can we confidently link bats with emerging deadly viruses?
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DOI：
10.1590/0074-02760150048
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发表时间：
2015-02
影响因子：
2.8
通讯作者：
Calisher CH
中科院分区：
文献类型：
--
作者：
Moratelli R;Calisher CH
一个越来越多的问题是“我们能确信蝙蝠与新出现的病毒联系起来吗？”'.根据现有的证据，“否”或"尚未“是有保留的答案。尽管已经从蝙蝠身上分离出或检测到了200多种病毒，其中一些是致命的人畜共患病毒，但蝙蝠、蝙蝠病毒和人类疾病之间的联系更多地是基于猜测，而不是基于支持它们在疾病流行病学中直接或间接作用的证据（狂犬病除外）。然而，我们相信，证据指向这个方向，在某个时候，它将被证明蝙蝠是至少一些人畜共患病毒的合格宿主。在这篇综述中，我们涵盖了蝙蝠生物学，生态学和进化方面，可能是相关的医学调查，我们提供了一个历史的综合因果关系与蝙蝠的一些疾病爆发。我们提供了基于进化的假设，以初步解释通过哺乳动物中间宿主的病毒传播途径，并解释大多数疫情的地理集中，但两者都只不过是猜测，仍然需要正式的评估。
An increasingly asked question is 'can we confidently link bats with emerging viruses?'. No, or not yet, is the qualified answer based on the evidence available. Although more than 200 viruses - some of them deadly zoonotic viruses - have been isolated from or otherwise detected in bats, the supposed connections between bats, bat viruses and human diseases have been raised more on speculation than on evidence supporting their direct or indirect roles in the epidemiology of diseases (except for rabies). However, we are convinced that the evidence points in that direction and that at some point it will be proved that bats are competent hosts for at least a few zoonotic viruses. In this review, we cover aspects of bat biology, ecology and evolution that might be relevant in medical investigations and we provide a historical synthesis of some disease outbreaks causally linked to bats. We provide evolutionary-based hypotheses to tentatively explain the viral transmission route through mammalian intermediate hosts and to explain the geographic concentration of most outbreaks, but both are no more than speculations that still require formal assessment.
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影响因子：
15.9
作者：
Brook CE;Dobson AP
通讯作者：
Dobson AP
影响因子：
56.9
作者：
Blehert, David S.;Hicks, Alan C.;Stone, Ward B.
通讯作者：
Stone, Ward B.
影响因子：
158.5
作者：
Baize, Sylvain;Pannetier, Delphine;Guenther, Stephan
通讯作者：
Guenther, Stephan
影响因子：
3.8
作者：
Barr, Jennifer A.;Smith, Craig;Wang, Lin-Fa
通讯作者：
Wang, Lin-Fa
DOI：
10.1093/geronj/46.2.b47
发表时间：
1991-03-01
期刊：
JOURNALS OF GERONTOLOGY
影响因子：
--
作者：
AUSTAD, SN;FISCHER, KE
通讯作者：
FISCHER, KE