NDF is a transcription factor that stimulates elongation by RNA polymerase II.
NDF is a transcription factor that stimulates elongation by RNA polymerase II.
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DOI：
10.1101/gad.349150.121
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发表时间：
2022-03-01
影响因子：
10.5
通讯作者：
Kadonaga JT
中科院分区：
文献类型：
--
作者：
Fei J;Xu J;Li Z;Xu K;Wang D;Kassavetis GA;Kadonaga JT
在这里，费等人。研究人员发现，NDF（被鉴定为双边对称核小体不稳定因子）也是一种 Pol II 转录因子，可在没有核小体的情况下刺激普通 DNA 模板的延伸。他们的研究结果表明，NDF 是一种 Pol II 结合转录延伸因子，位于基因体上，并且从酵母到人类都是保守的。 RNA 聚合酶 II (Pol II) 延伸是基因表达的关键步骤。在这里，我们发现 NDF（被鉴定为双边对称核小体不稳定因子）也是一种 Pol II 转录因子，可在没有核小体的情况下刺激普通 DNA 模板的延伸。 NDF 直接与 Pol II 结合，并通过与转录因子 TFIIS 不同的机制增强伸长。此外，与 NDF 相关的酵母 Pdp3 与 Pol II 结合并刺激伸长。因此，NDF 是一种 Pol II 结合转录延伸因子，位于基因体上，并且从酵母到人类都是保守的。
Here, Fei et al. found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. Their findings demonstrate that NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans. RNA polymerase II (Pol II) elongation is a critical step in gene expression. Here we found that NDF, which was identified as a bilaterian nucleosome-destabilizing factor, is also a Pol II transcription factor that stimulates elongation with plain DNA templates in the absence of nucleosomes. NDF binds directly to Pol II and enhances elongation by a different mechanism than that used by transcription factor TFIIS. Moreover, yeast Pdp3, which is related to NDF, binds to Pol II and stimulates elongation. Thus, NDF is a Pol II binding transcription elongation factor that is localized over gene bodies and is conserved from yeast to humans.
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