Analysis of ancestry heterozygosity suggests that hybrid incompatibilities in threespine stickleback are environment dependent.
Analysis of ancestry heterozygosity suggests that hybrid incompatibilities in threespine stickleback are environment dependent.
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对祖先杂合性的分析表明，三刺刺鱼的杂交不相容性是环境依赖性的。
DOI：
10.1371/journal.pbio.3001469
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发表时间：
2022-01
期刊：
影响因子：
9.8
通讯作者：
Schluter D
中科院分区：
文献类型：
--
作者：
Thompson KA;Peichel CL;Rennison DJ;McGee MD;Albert AYK;Vines TH;Greenwood AK;Wark AR;Brandvain Y;Schumer M;Schluter D
当不同基因座上的相反祖先等位基因之间的相互作用降低了杂种的适合度时，就会发生杂种不亲和。大多数关于不相容性的工作都集中在那些“内在的”，这意味着它们会影响实验室中的生存力和无菌性。理论预测，生态选择也可以成为杂种不亲和性的基础，但使用序列数据对这一假设进行检验的情况很少。本文以棘鱼（Gasterosteus aculeatus L.）在野外（自然实验池塘）或实验室（水族馆）出生和长大。由于选择不兼容的结果在祖先杂合性升高，我们测试的预测，祖先杂合性将更高的池塘饲养的鱼相比，在水族馆。我们发现，祖先杂合性升高了约3%，在池塘中提出的那些在水族馆相比，在十字架。进一步的分析支持不相容的表型基础，并表明环境特异性单位点杂合子优势不是祖先杂合性选择的原因。我们的研究提供的证据表明，在刺鱼，一个粗糙的，虽然间接的信号，环境依赖的混合不兼容性是可靠的检测，并表明，外在的不兼容性可以演变之前，内在的不兼容性。这项研究表明，两个独立的对杂交刺鱼种群之间的杂交不相容性只出现在相关的生态环境下，这意味着不相容性的演变之前，他们可以在实验室物种形成研究中检测到。
Hybrid incompatibilities occur when interactions between opposite ancestry alleles at different loci reduce the fitness of hybrids. Most work on incompatibilities has focused on those that are “intrinsic,” meaning they affect viability and sterility in the laboratory. Theory predicts that ecological selection can also underlie hybrid incompatibilities, but tests of this hypothesis using sequence data are scarce. In this article, we compiled genetic data for F2 hybrid crosses between divergent populations of threespine stickleback fish (Gasterosteus aculeatus L.) that were born and raised in either the field (seminatural experimental ponds) or the laboratory (aquaria). Because selection against incompatibilities results in elevated ancestry heterozygosity, we tested the prediction that ancestry heterozygosity will be higher in pond-raised fish compared to those raised in aquaria. We found that ancestry heterozygosity was elevated by approximately 3% in crosses raised in ponds compared to those raised in aquaria. Additional analyses support a phenotypic basis for incompatibility and suggest that environment-specific single-locus heterozygote advantage is not the cause of selection on ancestry heterozygosity. Our study provides evidence that, in stickleback, a coarse—albeit indirect—signal of environment-dependent hybrid incompatibility is reliably detectable and suggests that extrinsic incompatibilities can evolve before intrinsic incompatibilities. This study shows that hybrid incompatibilities between two independent pairs of hybridizing stickleback populations only appear under relevant ecological circumstances, implying that incompatibilities evolve before they can be detected in laboratory studies of speciation.
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DOI：
10.1139/f67-138
发表时间：
1967-01-01
期刊：
JOURNAL OF THE FISHERIES RESEARCH BOARD OF CANADA
影响因子：
--
作者：
HAGEN, DW
通讯作者：
HAGEN, DW
影响因子：
2.1
作者：
Breheny, Patrick;Burchett, Woodrow
通讯作者：
Burchett, Woodrow
影响因子：
8.8
作者：
Keagy, Jason;Lettieri, Liliana;Boughman, Janette W.
通讯作者：
Boughman, Janette W.
影响因子：
64.8
作者：
Arnegard, Matthew E.;McGee, Matthew D.;Matthews, Blake;Marchinko, Kerry B.;Conte, Gina L.;Kabir, Sahriar;Bedford, Nicole;Bergek, Sara;Chan, Yingguang Frank;Jones, Felicity C.;Kingsley, David M.;Peichel, Catherine L.;Schluter, Dolph
通讯作者：
Schluter, Dolph
影响因子：
3.3
作者：
Fox, Charles W.;Reed, David H.
通讯作者：
Reed, David H.