Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF.
Catalpol Induces Neuroprotection and Prevents Memory Dysfunction through the Cholinergic System and BDNF.
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梓醇通过胆碱能系统和 BDNF 诱导神经保护并预防记忆功能障碍
DOI：
10.1155/2013/134852
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Luo Y
中科院分区：
文献类型：
--
作者：
Wan D;Xue L;Zhu H;Luo Y
为探讨梓醇同时具有神经保护作用和记忆增强作用的机制，采用神经功能缺损评分、TTC染色、脑血流量测定等方法评价梓醇的神经保护作用。采用Morris水迷宫法研究其对学习记忆的影响，并探讨其与中枢胆碱能系统和脑源性神经营养因子（BDNF）的关系。根据依达拉奉和奥拉西坦作用的不同，分别选用依达拉奉和奥拉西坦作为阳性对照药。结果表明，梓醇和依达拉奉显著促进脑卒中小鼠神经功能恢复，减少梗死体积，增加脑血流量。梓醇和奥拉西坦明显缩短逃避潜伏期，明显增加穿越平台的次数。梓醇组ACh、ChAT和BDNF含量呈剂量依赖性升高，AChE含量呈U型剂量-反应曲线下降。梓醇还能显著提高海马M1和M2亚型AChR的表达水平。这些结果表明梓醇具有神经保护和增强记忆的作用，其机制可能与中枢胆碱能系统有关。
To investigate the role and mechanism of catalpol on neuroprotective effects and memory enhancing effects simultaneously, neuroprotective effects of catalpol were assessed by neurological deficits score, TTC staining, and cerebral blood flow detecting. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF. Edaravone and oxiracetam were used for positive control drugs based on its different action. Results showed that catalpol and edaravone significantly facilitated neurological function recovery, reduced infarction volume, and increased cerebral blood flow in stroke mice. Catalpol and oxiracetam decreased the escape latency significantly and increased the numbers of crossing platform obviously. The levels of ACh, ChAT, and BDNF in catalpol group were increased in a dose-dependent manner, and AChE declined with a U-shaped dose-response curve. Moreover, the levels of muscarinic AChR subtypes M1 and M2 in hippocampus were considerably raised by catalpol. These results demonstrated that catalpol may be useful for neuroprotection and memory enhancement, and the mechanism may be related to the central cholinergic system.
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影响因子：
8.3
作者：
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