The norepinephrine system and its relevance for multi-component behavior
The norepinephrine system and its relevance for multi-component behavior
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去甲肾上腺素系统及其与多成分行为的相关性
DOI：
10.1016/j.neuroimage.2016.10.007
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发表时间：
2017
期刊：
影响因子：
5.7
通讯作者：
Ziemssen
中科院分区：
文献类型：
--
作者：
Mückschel;Ziemssen
以特定时间顺序执行多个动作以实现总体目标的能力，通常称为动作级联或多组件行为的过程，对于日常生活需求至关重要。我们对这些认知过程重要的神经生物学机制的理解才刚刚开始。然而，蓝斑-去甲肾上腺素（LC-NE）系统可能是重要的。在目前的研究中，我们研究的相关性LC-NE系统的动作级联过程中使用的系统神经生理学方法相结合的高密度EEG记录和源定位分析事件相关电位（ERP）与瞳孔直径的记录作为LC-NE系统活动的近似。N=25名健康参与者进行了一个行动级联停止变化的范例。整合ERP和瞳孔直径使用皮尔逊相关，结果表明，LC-NE系统是重要的多成分行为相关的过程。然而，LC-NE系统似乎并不重要，在多成分行为（反映在P3）以及知觉和注意力选择（P1和N1 ERP）期间的反应选择过程的时间段。相反，它似乎是在一个可能即将到来的命令性刺激，以启动多组分行为的前期的神经生理过程与LC NE系统。似乎LC-NE系统促进了对任务相关过程的响应，并通过准备认知控制过程来支持任务相关的决策和响应选择过程，以防在多成分行为期间需要这些过程，而不是一旦这些过程开始操作就对其进行调制。
The ability to execute several actions in a specific temporal order to achieve an overarching goal, a process often termed action cascading or multi-component behavior, is essential for everyday life requirements. We are only at the beginning to understand the neurobiological mechanisms important for these cognitive processes. However, it is likely that the locus coeruleus-norepinephrine (LC-NE) system may be of importance. In the current study we examine the relevance of the LC-NE system for action cascading processes using a system neurophysiological approach combining high-density EEG recordings and source localization to analyze event-related potentials (ERPs) with recordings of pupil diameter as a proximate of LC-NE system activity. N=25 healthy participants performed an action cascading stop-change paradigm. Integrating ERPs and pupil diameter using Pearson correlations, the results show that the LC-NE system is important for processes related to multi-component behavior. However, the LC-NE system does not seem to be important during the time period of response selection processes during multi-component behavior (reflected in the P3) as well as during perceptual and attentional selection (P1 and N1 ERPs). Rather, it seems that the neurophysiological processes in the fore period of a possibly upcoming imperative stimulus to initiate multi-component behavior are correlated with the LC-NE system. It seems that the LC-NE system facilitates responses to task-relevant processes and supports task-related decision and response selection processes by preparing cognitive control processes in case these are required during multi-component behavior rather than modulating these processes once they are operating.
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影响因子：
3
作者：
Geva R;Zivan M;Warsha A;Olchik D
通讯作者：
Olchik D
人脑的注意力系统：20年后。
影响因子：
13.9
作者：
Petersen SE;Posner MI
通讯作者：
Posner MI
影响因子：
4.8
作者：
Yildiz, Ali;Quetscher, Clara;Dharmadhikari, Shalmali;Chmielewski, Witold;Glaubitz, Benjamin;Schmidt-Wilcke, Tobias;Edden, Richard;Dydak, Ulrike;Beste, Christian
通讯作者：
Beste, Christian
行动级联过程中任务目标处理策略与年龄相关的差异
影响因子：
3.1
作者：
A. Stock;K. Gohil;C. Beste
通讯作者：
C. Beste
影响因子：
4.6
作者：
Gohil K;Hahne A;Beste C
通讯作者：
Beste C