Pharmacodynamic activity of the lantibiotic MU1140.
Pharmacodynamic activity of the lantibiotic MU1140.
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DOI：
10.1016/j.ijantimicag.2008.07.028
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发表时间：
2009-01
影响因子：
10.8
通讯作者：
Hillman, Jeffery D.
中科院分区：
文献类型：
--
作者：
Ghobrial, Oliver G.;Derendorf, Hartmut;Hillman, Jeffery D.
本研究评价了羊毛硫抗生素MU1140的药效学和选定生物体对该抗生素产生耐药性的能力。MU1140对所有测试的革兰氏阳性微生物都表现出活性，包括苯唑西林和万古霉素耐药金黄色葡萄球菌和万古霉素耐药粪肠球菌（VREF）。未观察到对革兰氏阴性细菌或酵母的活性。时间杀灭研究表明，MU1140对肺炎链球菌和多重耐药链球菌具有快速杀菌作用。金黄色葡萄球菌，而它对VREF是抑菌的。通过在亚抑制浓度的MU1140中连续传代培养测试的对MU1140的体外耐药性发展显示，S.金黄色葡萄球菌和肺炎。随后将MIC升高的菌株在无菌培养基中传代培养7天，未导致其对MU1140的MIC值降低。总的来说，我们的研究结果说明了MU1140用于管理革兰氏阳性菌感染的治疗潜力。
This study evaluated the pharmacodynamics of the lantibiotic MU1140 and the ability of selected organisms to develop resistance to this antibiotic. MU1140 demonstrated activity against all Gram-positive organisms tested, including oxacillin- and vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis (VREF). No activity was observed against Gram-negative bacteria or yeast. Time–kill studies revealed that MU1140 was rapidly bactericidal against Streptococcus pneumoniae and multidrug-resistant S. aureus, whilst it was bacteriostatic against VREF. In vitro resistance development to MU1140, tested by sequential subculturing in subinhibitory concentrations of MU1140, revealed a stable three-fold increase in the minimum inhibitory concentration (MIC) for S. aureus and S. pneumoniae. Subsequent subculturing of the strains with elevated MICs in antibiotic-free media for 7 days did not result in a reduction of their MIC values for MU1140. Collectively, our findings illustrate the therapeutic potential of MU1140 for management of Gram-positive infections.
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影响因子：
3.1
作者：
HILLMAN, JD;JOHNSON, KP;YAPHE, BI
通讯作者：
YAPHE, BI
影响因子：
4.9
作者：
BAILEY, EM;RYBAK, MJ;KAATZ, GW
通讯作者：
KAATZ, GW
影响因子：
2.9
作者：
Smith, Leif;Hasper, Hester;Orugunty, Ravi S.
通讯作者：
Orugunty, Ravi S.
DOI：
10.1179/096805105x37394
发表时间：
2005-01-01
期刊：
JOURNAL OF ENDOTOXIN RESEARCH
影响因子：
--
作者：
Bowdish, DME;Hancock, REW
通讯作者：
Hancock, REW
影响因子：
56.9
作者：
Hasper, Hester E.;Kramer, Naomi E.;Breukink, Eefjan
通讯作者：
Breukink, Eefjan