A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population.
A Psychometrically Robust Screening Tool To Rapidly Identify Socially Impaired Monkeys In The General Population.
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DOI：
10.1002/aur.2335
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Parker KJ
中科院分区：
文献类型：
--
作者：
Talbot CF;Garner JP;Maness AC;McCowan B;Capitanio JP;Parker KJ
自然低社会性恒河猴表现出与自闭症谱系障碍（ASD）直接相关的社交障碍。为了在大群体中更有效地识别低社会个体，我们利用、改进和心理测量学评估了猕猴社会反应量表（mSRS），这是一种先前源自人类ASD筛查工具的工具。我们对总共N = 349只猕猴（Macaca mulatta）进行了定量的社会行为评估和mSRS评级，这些猕猴被安置在大型室外围栏中。在一个队列（N = 116）中，我们进行了评估者间信度和重测信度，在另一个队列（N = 233）中，我们评估了msrs -修订版（mSRS-R）的收敛结构和预测效度。在原来的36个项目中，只有17个项目的mSRS-R具有测验间信度和重测信度，从而产生了17个项目的mSRS-R。mSRS-R显示出较强的效度：mSRS-R分数能有效预测猴子在家庭畜栏中的社会行为频率。在非社会行为上得分离平均值1.5标准差的猴子同样表现出更多的自闭症样特征，mSRS-R得分预测个体的社会分类（低社会与高社会）的准确率为96%（似然比卡方= 25.07;P < 0.0001）。这些发现表明，mSRS-R是一种可靠、有效和敏感的社会功能测量方法，与人类SRS一样，可以作为一种高通量筛选工具，在普通人群中识别社会障碍个体。自闭症特征的变异可以用社会反应量表（Social Responsiveness Scale， SRS）来测量。在这里，我们修改了恒河猴的这个量表（即mSRS-R），并表明恒河猴在mSRS-R得分上表现出个体差异，在行为的极端情况下，低社会性与高社会性的猴子表现出更多的自闭症特征。这些结果表明，mSRS-R可以作为一种筛选工具，快速准确地识别普通群体中的低社会性猴子。
Naturally low-social rhesus macaques exhibit social impairments with direct relevance to autism spectrum disorder (ASD). To more efficiently identify low-social individuals in a large colony, we exploited, refined, and psychometrically assessed the macaque Social Responsiveness Scale (mSRS), an instrument previously derived from the human ASD screening tool. We performed quantitative social behavior assessments and mSRS ratings on a total of N = 349 rhesus macaques (Macaca mulatta) housed in large, outdoor corrals. In one cohort (N = 116), we conducted inter-rater and test-retest reliabilities, and in a second cohort (N = 233), we evaluated the convergent construct and predictive validity of the mSRS-Revised (mSRS-R). Only 17 of the original 36 items demonstrated inter-rater and test–retest reliability, resulting in the 17-item mSRS-R. The mSRS-R showed strong validity: mSRS-R scores robustly predicted monkeys’ social behavior frequencies in home corrals. Monkeys that scored 1.5 standard deviations from the mean on nonsocial behavior likewise exhibited significantly more autistic-like traits, and mSRS-R scores predicted individuals’ social classification (low-social vs. high-social) with 96% accuracy (likelihood ratio chi-square = 25.07; P < 0.0001). These findings indicate that the mSRS-R is a reliable, valid, and sensitive measure of social functioning, and like the human SRS, can be used as a high-throughput screening tool to identify socially impaired individuals in the general population. Variation in autistic traits can be measured in humans using the Social Responsiveness Scale (SRS). Here, we revised this scale for rhesus macaques (i.e., the mSRS-R), and showed that macaques exhibit individual differences in mSRS-R scores, and at the behavioral extremes, low-social vs. high-social monkeys exhibit more autistic-like traits. These results suggest that the mSRS-R can be used as a screening tool to rapidly and accurately identify low-social monkeys in the general population.
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DOI：
10.1176/appi.ajp.2010.09101470
发表时间：
2010-11
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Constantino JN;Zhang Y;Frazier T;Abbacchi AM;Law P
通讯作者：
Law P
影响因子：
10.6
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD
影响因子：
3.9
作者：
Constantino, JN;Davis, SA;Reich, W
通讯作者：
Reich, W
影响因子：
3.7
作者：
Feczko EJ;Bliss-Moreau E;Walum H;Pruett JR Jr;Parr LA
通讯作者：
Parr LA
影响因子：
2.5
作者：
Jussila, Katja;Kuusikko-Gauffin, Sanna;Hurtig, Tuula
通讯作者：
Hurtig, Tuula