Nickel-Catalyzed Chemo- and Enantioselective Coupling between Cyclobutanones and Allenes: Rapid Synthesis of [3.2.2] Bicycles.
Nickel-Catalyzed Chemo- and Enantioselective Coupling between Cyclobutanones and Allenes: Rapid Synthesis of [3.2.2] Bicycles.
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DOI：
10.1002/anie.201609489
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发表时间：
2016-11-21
影响因子：
16.6
通讯作者：
Dong, Guangbin
中科院分区：
文献类型：
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作者：
Zhou, Xuan;Dong, Guangbin
Herein an intramolecular Ni-catalyzed (4+2) coupling between cyclobutanones and allenes via C–C cleavage is reported, which provides a distinct approach to access [3.2.2] bicyclic scaffolds that are challenging to prepare through conventional approaches. The reaction is efficient, chemoselective and pH/redox neutral. Room temperature conditions and low catalyst loadings can be adopted. Excellent enantioselectivity is also achieved. An intramolecular Ni-catalyzed (4+2) coupling between cyclobutanones and allenes via C–C cleavage is reported, which provides a unique approach to access [3.2.2] bicyclic scaffolds. The reaction is efficient, chemoselective and pH/redox neutral. Excellent enantioselectivity is also achieved.
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