Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients.
Continuous low- to moderate-intensity exercise training is as effective as moderate- to high-intensity exercise training at lowering blood HbA(1c) in obese type 2 diabetes patients.
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DOI：
10.1007/s00125-009-1354-3
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发表时间：
2009-09
期刊：
影响因子：
8.2
通讯作者：
van Loon, L. J. C.
中科院分区：
文献类型：
--
作者：
Hansen, D.;Dendale, P.;Jonkers, R. A. M.;Beelen, M.;Manders, R. J. F.;Corluy, L.;Mullens, A.;Berger, J.;Meeusen, R.;van Loon, L. J. C.
运动是改善2型糖尿病患者血糖控制的有效干预策略。然而，运动强度对运动训练益处的影响仍有待确定。在本研究中，我们比较了肥胖2型糖尿病患者6个月连续低强度至中等强度运动训练与连续中等强度至高强度运动训练的临床益处，并与能量消耗相匹配。50例男性肥胖2型糖尿病患者（年龄59 ± 8岁，BMI 32 ± 4 kg/m2）参加了6个月的连续性运动训练计划。所有参与者每周进行三次有监督的运动，无论是55分钟的全身峰值摄氧量的50%（低至中等强度）或40分钟的75%（中至高强度）。在干预前、干预后2个月和干预后6个月，对口服葡萄糖耐量、糖化血红蛋白、血脂、身体组成、最大工作负荷能力、全身和骨骼肌氧化能力以及骨骼肌纤维类型组成进行评估。37名参与者完成了整个6个月的干预方案。持续耐力型运动训练降低了血液糖化血红蛋白水平、LDL-胆固醇浓度、体重和腿部脂肪质量，增加了瘦肌肉质量和骨骼肌细胞色素c氧化酶和柠檬酸合酶活性（p < 0.05）。在低到中等或中等到高强度训练的组之间没有观察到差异。当与能量消耗相匹配时，在肥胖的2型糖尿病患者中，长期持续的低强度至中等强度的耐力型运动训练与持续的中等强度至高强度的训练在降低血液糖化血红蛋白和增加全身和骨骼肌氧化能力方面同样有效。ISRCTN 32206301无
Exercise represents an effective interventional strategy to improve glycaemic control in type 2 diabetes patients. However, the impact of exercise intensity on the benefits of exercise training remains to be established. In the present study, we compared the clinical benefits of 6 months of continuous low- to moderate-intensity exercise training with those of continuous moderate- to high-intensity exercise training, matched for energy expenditure, in obese type 2 diabetes patients. Fifty male obese type 2 diabetes patients (age 59 ± 8 years, BMI 32 ± 4 kg/m2) participated in a 6 month continuous endurance-type exercise training programme. All participants performed three supervised exercise sessions per week, either 55 min at 50% of whole body peak oxygen uptake (low to moderate intensity) or 40 min at 75% of (moderate to high intensity). Oral glucose tolerance, blood glycated haemoglobin, lipid profile, body composition, maximal workload capacity, whole body and skeletal muscle oxidative capacity and skeletal muscle fibre type composition were assessed before and after 2 and 6 months of intervention. The entire 6 month intervention programme was completed by 37 participants. Continuous endurance-type exercise training reduced blood glycated haemoglobin levels, LDL-cholesterol concentrations, body weight and leg fat mass, and increased , lean muscle mass and skeletal muscle cytochrome c oxidase and citrate synthase activity (p < 0.05). No differences were observed between the groups training at low to moderate or moderate to high intensity. When matched for energy cost, prolonged continuous low- to moderate-intensity endurance-type exercise training is equally effective as continuous moderate- to high-intensity training in lowering blood glycated haemoglobin and increasing whole body and skeletal muscle oxidative capacity in obese type 2 diabetes patients. ISRCTN32206301 None
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影响因子：
8.2
作者：
Larsen, JJS;Dela, F;Galbo, H
通讯作者：
Galbo, H
影响因子：
3.3
作者：
DiPietro, L;Dziura, J;Neufer, PD
通讯作者：
Neufer, PD
DOI：
10.1073/pnas.1032913100
发表时间：
2003-07-08
影响因子：
11.1
作者：
Patti, ME;Butte, AJ;Mandarino, LJ
通讯作者：
Mandarino, LJ
影响因子：
16.2
作者：
De Feyter, Henk M.;Praet, Stephan F.;van Loon, Luc J. C.
通讯作者：
van Loon, Luc J. C.
影响因子：
15.9
作者：
Bonnard, Charlotte;Durand, Annie;Rieusset, Jennifer
通讯作者：
Rieusset, Jennifer