Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer.
Competing Endogenous RNA Networks in the Epithelial to Mesenchymal Transition in Diffuse-Type of Gastric Cancer.
复制标题
DOI：
10.3390/cancers12102741
复制
发表时间：
2020-09-24
期刊：
影响因子：
5.2
通讯作者：
Corvalan AH
中科院分区：
文献类型：
--
作者：
Landeros N;Santoro PM;Carrasco-Avino G;Corvalan AH
弥漫性胃癌与上皮向间质转化有关。E-cadherin表达的缺失是这一过程的标志，主要是由于转录因子ZEB1/2、Snail、Slug和Twist1/2的上调。而miRNA和lncrna也可以通过这些直接靶向E-cadherin的转录因子参与其中。竞争内源性RNA （ceRNA）网络假说认为，lncRNA可以吞噬靶向这些转录物的miRNA池。基于上皮细胞向间质细胞转化过程中缺乏上述网络，我们进行了预测分析，发现了新的ceRNA网络，这将扩大我们对弥漫性胃癌分子基础的了解。与上皮细胞向间质转化（EMT）分子相关的弥漫性胃癌（DGC）的发病率正在增加。E-cadherin表达的缺失是EMT过程的标志，主要是由于EMT诱导转录因子ZEB1/2、Snail、Slug和Twist1/2的上调。然而，miRNA、lncrna等ncRNA也可以通过直接靶向E-cadherin等诱导EMT的转录因子参与EMT过程。此外，lncRNA可以通过竞争的内源性RNA （ceRNA）网络吸收靶向这些转录本的miRNA池。在这篇综述中，我们重点介绍了ncRNA在E-cadherin和emt诱导转录因子的直接调控中的作用。基于ceRNA网络假设的相关性，以及EMT中缺乏该网络，我们对所有靶向E-cadherin的mirna和lncrna以及EMT诱导转录因子进行了预测分析。该分析结果预测了E-cadherin和emt诱导转录因子（emt - tf）的新型ceRNA网络，并扩展了DGC的分子基础。
The diffuse-type of gastric cancer is associated with epithelial to mesenchymal transition. Loss of E-cadherin expression is the hallmark of this process and is largely due to the upregulation of the transcription factors ZEB1/2, Snail, Slug, and Twist1/2. However, miRNA and lncRNAs can also participate through these transcription factors which directly target E-cadherin. The competing endogenous RNA (ceRNA) network hypothesis state that lncRNA can sponge the miRNA pool that targets these transcripts. Based on the lack of said networks in the epithelial to mesenchymal transition, we performed a prediction analysis that resulted in novel ceRNA networks which will expand our knowledge of the molecular basis of the diffuse-type of gastric cancer. The diffuse-type of gastric cancer (DGC), molecularly associated with epithelial to mesenchymal transition (EMT), is increasing in incidence. Loss of E-cadherin expression is the hallmark of the EMT process and is largely due to the upregulation of the EMT-inducing transcription factors ZEB1/2, Snail, Slug, and Twist1/2. However, ncRNA, such as miRNA and lncRNAs, can also participate in the EMT process through the direct targeting of E-cadherin and other EMT-inducing transcription factors. Additionally, lncRNA can sponge the miRNA pool that targets these transcripts through competing endogenous RNA (ceRNA) networks. In this review, we focus on the role of ncRNA in the direct deregulation of E-cadherin, as well as EMT-inducing transcription factors. Based on the relevance of the ceRNA network hypothesis, and the lack of said networks in EMT, we performed a prediction analysis for all miRNAs and lncRNAs that target E-cadherin, as well as EMT-inducing transcription factors. This analysis resulted in novel predicted ceRNA networks for E-cadherin and EMT-inducing transcription factors (EMT-TFs), as well as the expansion of the molecular basis of the DGC.
登录
查看更多内容
影响因子：
--
作者：
Cao C;Sun D;Zhang L;Song L
通讯作者：
Song L
DOI：
10.1038/nrc.2017.99
发表时间：
2018-01
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Anastasiadou E;Jacob LS;Slack FJ
通讯作者：
Slack FJ
影响因子：
2.3
作者：
Bonequi, Patricia;Meneses-Gonzalez, Fernando;Correa, Pelayo;Rabkin, Charles S.;Constanza Camargo, M.
通讯作者：
Constanza Camargo, M.
DOI：
10.1152/ajpgi.00284.2018
发表时间：
2019-08-01
影响因子：
4.5
作者：
Chen, Di-Di;Cheng, Jiang-Ting;Huang, Ying-Peng
通讯作者：
Huang, Ying-Peng
影响因子：
21.3
作者：
Batlle, E;Sancho, E;de Herreros, AG
通讯作者：
de Herreros, AG