Risk factors for gastric cancer in Latin America: a meta-analysis.
Risk factors for gastric cancer in Latin America: a meta-analysis.
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DOI：
10.1007/s10552-012-0110-z
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发表时间：
2013-02
影响因子：
2.3
通讯作者：
Constanza Camargo, M.
中科院分区：
文献类型：
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作者：
Bonequi, Patricia;Meneses-Gonzalez, Fernando;Correa, Pelayo;Rabkin, Charles S.;Constanza Camargo, M.
拉丁美洲是世界上胃癌发病率最高的地区之一，原因尚不清楚。为了确定胃癌的区域特异性危险因素，我们进行了一项荟萃分析，总结了已发表的文献。检索PubMed和区域数据库中截至2011年12月发表的相关研究，共获得29项独立病例对照研究。我们计算了至少五项研究中报告的风险因素的汇总比值比（OR），包括社会经济地位（教育）、生活习惯（吸烟和饮酒），饮食因素（水果、蔬菜总量、绿色蔬菜、辣椒、肉类总量、加工肉类、红肉、鱼和盐的消费）和宿主遗传变异（IL 1B-511 T、IL 1B-31 C、IL 1 RN *2、TNFA-308 A、TP 53密码子72 Arg和GSTM 1无效）。使用随机效应模型提取并总结研究特定OR。辣椒是至少五项研究中报告的唯一地区特异性因素。与多因素发病机制一致，吸烟、饮酒、大量食用红肉或加工肉类、过量摄入盐和携带IL 1 RN *2均与胃癌风险中度增加相关。相反，较高的教育水平，水果消费量和蔬菜总消费量均与风险适度降低相关。其他暴露无显著相关性。未发现前瞻性研究数据。拉丁美洲胃癌的危险因素关联是基于病例对照比较，其可靠性不确定，特别是在饮食方面;确定的具体因素及其关联程度与全球公认的因素基本相似。未来的研究应强调前瞻性数据收集，并关注可能解释胃癌高风险的区域特定暴露。
Latin America has among the highest gastric cancer incidence rates in the world, for reasons that are still unknown. In order to identify region-specific risk factors for gastric cancer, we conducted a meta-analysis summarizing published literature. Searches of PubMed and regional databases for relevant studies published up to December 2011 yielded a total of 29 independent case-control studies. We calculated summary odds ratios (OR) for risk factors reported in at least five studies, including socioeconomic status (education), lifestyle habits (smoking and alcohol use), dietary factors (consumption of fruits, total vegetables, green vegetables, chili pepper, total meat, processed meat, red meat, fish and salt) and host genetic variants (IL1B-511T, IL1B-31C, IL1RN*2, TNFA-308A, TP53 codon 72 Arg and GSTM1 null). Study-specific ORs were extracted and summarized using random-effects models. Chili pepper was the only region-specific factor reported in at least five studies. Consistent with multifactorial pathogenesis, smoking, alcohol use, high consumption of red meat or processed meat, excessive salt intake and carriage of IL1RN*2 were each associated with a moderate increase in gastric cancer risk. Conversely, higher levels of education, fruit consumption, and total vegetable consumption were each associated with a moderately decreased risk. The other exposures were not significantly associated. No prospective study data were identified. Risk factor associations for gastric cancer in Latin America are based on case-control comparisons that have uncertain reliability, particularly with regard to diet; the specific factors identified and their magnitudes of association are largely similar to those globally recognized. Future studies should emphasize prospective data collection and focus on region-specific exposures that may explain high gastric cancer risk.
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影响因子：
24.5
作者：
de Sablet T;Piazuelo MB;Shaffer CL;Schneider BG;Asim M;Chaturvedi R;Bravo LE;Sicinschi LA;Delgado AG;Mera RM;Israel DA;Romero-Gallo J;Peek RM Jr;Cover TL;Correa P;Wilson KT
通讯作者：
Wilson KT
影响因子：
4.3
作者：
Campos, Francia;Carrasquilla, Gabriel;Akiba, Suminori
通讯作者：
Akiba, Suminori
影响因子：
4.6
作者：
Alpízar-Alpízar, W;Pérez-Pérez, GI;Sierra, R
通讯作者：
Sierra, R
影响因子：
5.4
作者：
Cardenas, VM;Graham, DY
通讯作者：
Graham, DY
影响因子：
30.8
作者：
通讯作者：
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