Characteristics of human infection with avian influenza viruses and development of new antiviral agents.
Characteristics of human infection with avian influenza viruses and development of new antiviral agents.
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DOI：
10.1038/aps.2013.121
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发表时间：
2013-10
影响因子：
8.2
通讯作者：
Yang, Zhan-qiu
中科院分区：
文献类型：
--
作者：
Liu, Qiang;Liu, Dong-ying;Yang, Zhan-qiu
关键词：
自1997年以来，几种流行性禽流感病毒（AIV）已传播给人类，造成疾病甚至死亡。最近在中国出现了严重的人感染AIV（H7N9）的情况，引起了人们对有效的人际病毒传播、病毒致病性的多基因特征和新出现毒株的管理的关注。不同的禽流感病毒株与病毒感染相关的症状不同：H5N1和新出现的H7N9引起患者严重的肺炎和相关并发症，而一些H7和H9亚型仅引起结膜炎或轻微的呼吸道症状。病毒的毒力和组织嗜性以及宿主的免疫反应是导致人类AIV感染的重要原因。针对AIV的感染，目前已提出了多种预防和治疗方法，包括M2抑制剂、神经氨酸酶抑制剂、RNA聚合酶抑制剂、粘附抑制剂和信号转导抑制剂等抗病毒药物。本文就AIV的流行病学、临床特征、致病性决定因素以及现有或潜在的抗病毒药物的研究进展进行综述。
Since 1997, several epizootic avian influenza viruses (AIVs) have been transmitted to humans, causing diseases and even deaths. The recent emergence of severe human infections with AIV (H7N9) in China has raised concerns about efficient interpersonal viral transmission, polygenic traits in viral pathogenicity and the management of newly emerging strains. The symptoms associated with viral infection are different in various AI strains: H5N1 and newly emerged H7N9 induce severe pneumonia and related complications in patients, while some H7 and H9 subtypes cause only conjunctivitis or mild respiratory symptoms. The virulence and tissue tropism of viruses as well as the host responses contribute to the pathogenesis of human AIV infection. Several preventive and therapeutic approaches have been proposed to combat AIV infection, including antiviral drugs such as M2 inhibitors, neuraminidase inhibitors, RNA polymerase inhibitors, attachment inhibitors and signal-transduction inhibitors etc. In this article, we summarize the recent progress in researches on the epidemiology, clinical features, pathogenicity determinants, and available or potential antivirals of AIV.
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影响因子：
3.7
作者：
Brett SJ;Myles P;Lim WS;Enstone JE;Bannister B;Semple MG;Read RC;Taylor BL;McMenamin J;Nicholson KG;Nguyen-Van-Tam JS;Openshaw PJ;Influenza Clinical Information Network (FLU-CIN)
通讯作者：
Influenza Clinical Information Network (FLU-CIN)
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作者：
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通讯作者：
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影响因子：
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作者：
Butt, KM;Smith, GJD;Guan, Y
通讯作者：
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影响因子：
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通讯作者：
Selleck P
影响因子：
11.8
作者：
Al-Azemi A;Bahl J;Al-Zenki S;Al-Shayji Y;Al-Amad S;Chen H;Guan Y;Peiris JS;Smith GJ
通讯作者：
Smith GJ