Inhibition of cell invasion and migration by CEACAM1-4S in breast cancer.
Inhibition of cell invasion and migration by CEACAM1-4S in breast cancer.
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CEACAM1-4S 对乳腺癌细胞侵袭和迁移的抑制
DOI：
10.3892/ol.2017.6791
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发表时间：
2017-10
期刊：
影响因子：
2.9
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Yang C;Cao M;Liu Y;He Y;Yang C;Du Y;Wang W;Zhang G;Wu M;Zhou M;Gao F
癌胚抗原相关细胞粘附分子1（CEACAM 1）是一种细胞间粘附分子，在肿瘤的发生、发展过程中起重要作用。虽然有许多关于乳腺癌患者中CEACAM 1的研究，但关于CEACAM 1在乳腺癌转移中的作用的信息有限。本研究旨在确定CEACAM 1是否参与乳腺癌的发展，并探讨其潜在机制。首先，在乳腺癌患者中观察CEACAM 1的表达，并分析CEACAM 1表达水平与乳腺癌细胞迁移和侵袭之间的关联。由于CEACAM 1有12种亚型，其中CEACAM 1 -4S在人乳腺上皮中占主导地位，因此随后的研究集中在CEACAM 1 -4S作为所有亚型的代表。本研究的结果表明，CEACAM 1 -4S抑制乳腺癌细胞的侵袭和迁移的方式是依赖于基质金属蛋白酶2/金属蛋白酶2和E-/N-钙粘蛋白表达的组织抑制剂之间的平衡。此外，CEACAM 1 -4S可能通过抑制Smad 2和信号转导子以及转录激活子3的磷酸化，逆转乳腺癌细胞的上皮-间质转化。总之，本研究表明CEACAM 1 -4S在乳腺癌转移中起抑制作用，恢复CEACAM 1 -4S表达可能为转移性乳腺癌患者的治疗提供新的策略。
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), a cell-cell adhesion molecule, has been revealed to perform an important role in tumor progression. Although there are a number of studies on CEACAM1 in patients with breast cancer, there is limited information on the roles of CEACAM1 in breast cancer metastasis. The present study aimed to identify whether CEACAM1 is involved in breast cancer development and to investigate the underlying mechanisms. First, the expression of CEACAM1 was observed in patients with breast cancer, and the association between CEACAM1 expression levels and migration and invasion of breast cancer cells was analyzed. As there are 12 isoforms of CEACAM1, of which CEACAM1-4S dominates in the human breast epithelium, subsequent study focused on CEACAM1-4S as a representative of all the isoforms. Results of the present study demonstrated that CEACAM1-4S suppresses breast cancer cell invasion and migration in a manner that is dependent on the balance between matrix metalloproteinase 2/tissue inhibitor of metalloproteinase 2 and E-/N-cadherin expression. In addition, CEACAM1-4S was likely to cause reversal of epithelial-mesenchymal transition of breast cancer cells through repressing Smad2 and signal transducer and phosphorylation of activator of transcription 3. In conclusion, the present study demonstrated that CEACAM1-4S performs an inhibitory role in breast cancer metastasis, and restoring CEACAM1-4S expression may provide a novel strategy for therapy of patients with metastatic breast cancer.
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DOI：
10.1016/j.bbrc.2012.11.107
发表时间：
2013-01-11
影响因子：
3.1
作者：
Liu, Jin;Di, Guohu;Duan, Haifeng
通讯作者：
Duan, Haifeng
影响因子：
8
作者：
Liu, W.;Wei, W.;Asa, S. L.
通讯作者：
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影响因子：
21.3
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影响因子：
5.2
作者：
Said AH;Raufman JP;Xie G
通讯作者：
Xie G
DOI：
10.1038/nrm3758
发表时间：
2014-03
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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