The REST gene signature predicts drug sensitivity in neuroblastoma cell lines and is significantly associated with neuroblastoma tumor stage.
The REST gene signature predicts drug sensitivity in neuroblastoma cell lines and is significantly associated with neuroblastoma tumor stage.
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REST 基因特征可预测神经母细胞瘤细胞系的药物敏感性，并与神经母细胞瘤肿瘤阶段显着相关
DOI：
10.3390/ijms150711220
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发表时间：
2014-06-25
影响因子：
5.6
通讯作者：
Yu Y
中科院分区：
文献类型：
--
作者：
Liang J;Tong P;Zhao W;Li Y;Zhang L;Xia Y;Yu Y
神经母细胞瘤是儿童中最常见和致命的实体瘤，目前尚无有效的治疗方法可用于神经母细胞瘤患者。阻遏元件-1沉默转录因子（repressor element-1 silencing transcription，REST）在神经分化和肿瘤发生中起重要作用。最近，据报道，由REST下游靶点组成的REST签名在乳腺癌和胶质母细胞瘤中具有临床相关性。然而，目前尚不清楚REST签名如何在神经母细胞瘤中起作用。公开可用的数据集进行挖掘，并使用生物信息学方法来研究REST签名在神经母细胞瘤中的实用性，包括临床前和真实的患者数据。REST签名被发现与神经母细胞瘤细胞系中的药物敏感性相关。此外，具有增强的REST活性的神经母细胞瘤患者与更高的临床分期显著相关。染色体11 q23的杂合性缺失，发生在一个大的子集的高风险神经母细胞瘤，往往与高REST活性，边际意义。总之，REST签名对靶向治疗具有重要意义，并且它是神经母细胞瘤患者的预后因素。
Neuroblastoma is the most common and deadly solid tumor in children, and there is currently no effective treatment available for neuroblastoma patients. The repressor element-1 silencing transcription (REST) factor has been found to play important roles in the regulation of neural differentiation and tumorigenesis. Recently, a REST signature consisting of downstream targets of REST has been reported to have clinical relevance in both breast cancer and glioblastoma. However it remains unclear how the REST signature works in neuroblastoma. Publicly available datasets were mined and bioinformatic approaches were used to investigate the utility of the REST signature in neuroblastoma with both preclinical and real patient data. The REST signature was found to be associated with drug sensitivity in neuroblastoma cell lines. Further, neuroblastoma patients with enhanced REST activity are significantly associated with higher clinical stages. Loss of heterozygosity on chromosome 11q23, which occurs in a large subset of high-risk neuroblastomas, tends to be correlated with high REST activity, with marginal significance. In conclusion, the REST signature has important implications for targeted therapy, and it is a prognostic factor in neuroblastoma patients.
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影响因子：
5.6
作者：
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作者：
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