Hot flashes and cardiac vagal control during women's daily lives.
Hot flashes and cardiac vagal control during women's daily lives.
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DOI：
10.1097/gme.0b013e3182337166
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Matthews KA
中科院分区：
文献类型：
--
作者：
Thurston RC;Christie IC;Matthews KA
绝经期潮热的生理学尚未完全了解。自主神经系统可能在潮热中发挥作用，但目前的理解是有限的。我们先前在实验室中证明，相对于之前和之后的时期，在潮热期间发生高频心率变异性（心脏迷走神经控制的指标）的降低。在本研究中，我们测试了我们是否会在门诊环境中观察到类似的现象。我们还考虑了这些相关性中的呼吸频率。21名年龄在40-60岁的绝经期和绝经后妇女每天报告潮热，在她们日常生活的24小时内监测生理潮热和报告潮热以及心率变异性。心率变异性估计使用带限方差法。通过混合效应模型，将潮热期间的间隔与潮热之前和之后的两个非潮热期进行比较。相对于生理性潮热之前（B=0.31，SE=0.03，p<0.0001）和之后（B=0.30，SE=0.03，p<0.0001），潮热期间心率变异性显著降低（协变量：年龄、种族、教育、绝经状态、体力活动、体重指数、焦虑）。考虑到自我报告的潮热，结果相当。控制呼吸频率后，结果持续存在。在妇女的日常生活中评估的潮热期间，心脏迷走神经控制发生显着下降。这些发现将我们在实验室的工作扩展到了门诊环境，进一步阐明了潮热的生理学，并强调了副交感神经功能在潮热中的潜在作用。
The physiology of menopausal hot flashes is not well understood. The autonomic nervous system may play a role in hot flashes, but the current understanding is limited. We previously demonstrated in the laboratory that decreases in high frequency heart rate variability, an index of cardiac vagal control, occur during hot flashes relative to preceding and following periods. In the present study, we tested whether we would observe a similar phenomenon in the ambulatory setting. We additionally considered respiratory rate in these associations. 21 peri- and postmenopausal women ages 40–60 reporting daily hot flashes were monitored both for physiologic and reported hot flashes and heart rate variability over a 24-hour period as they went about their daily lives. Heart rate variability estimates were derived using the band-limited variance method. The interval during the hot flash was compared to two non-flash periods prior to and following the hot flash via mixed effects models. Heart rate variability significantly decreased during hot flashes relative to periods preceding (b=0.31, SE=0.03 p<0.0001) and following (b=0.30, SE=0.03, p<0.0001) physiologic hot flashes (covariates: age, race, education, menopausal status, physical activity, body mass index, anxiety). Findings were comparable considering self-reported hot flashes. Findings persisted controlling for respiratory rate. Significant decreases in cardiac vagal control occurred during hot flashes assessed during women’s daily lives. These findings extend our work in the laboratory to the ambulatory setting, further shedding light on the physiology of hot flashes and underscoring a potential role of parasympathetic function in hot flashes.
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影响因子：
12.7
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
通讯作者：
Matthews, Karen
DOI：
10.1097/gme.0b013e31819c11e4
发表时间：
2009-07
期刊：
Menopause (New York, N.Y.)
影响因子：
--
作者：
Huang AJ;Sawaya GF;Vittinghoff E;Lin F;Grady D
通讯作者：
Grady D
DOI：
10.1097/00042192-199906030-00006
发表时间：
1999-09-01
影响因子：
2.7
作者：
Carpenter, JS;Andrykowski, MA;Munn, R
通讯作者：
Munn, R
DOI：
10.1097/01.gme.0000030707.35686.5a
发表时间：
2003-01-01
影响因子：
2.7
作者：
Kravitz, HM;Ganz, PA;Meyer, PM
通讯作者：
Meyer, PM
影响因子：
8.3
作者：
Gast, Gerrie-Cor M.;Grobbee, Diederick E.;van der Schouw, Yvonne T.
通讯作者：
van der Schouw, Yvonne T.